Publications associées à Transcription factor Jun

Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder

Dylan Lawless, Beibei Wu

CRAC channel regulator 2 A (CRACR2A) is a large Rab GTPase that is expressed abundantly in T cells and acts as a signal transmitter between T cell receptor stimulation and activation of the Ca2+-NFAT and JNK-AP1 pathways. CRACR2A has been linked to human d ...

eLIFE SCIENCES PUBL LTD2021

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

Paul Joseph Dyson, Laure Menin, Wee Han Ang

Cisplatin [cis-diamminedichloroplatinum(II) (cis-DDP)] is one of the most successful anticancer agents effective against a wide range of solid tumors. However, its use is restricted by side effects and/or by intrinsic or acquired drug resistance. Here, we ...

PNAS2019

DPPA2 and DPPA4 are necessary to establish a 2C‐like state in mouse embryonic stem cells

Didier Trono, Julien Léonard Duc, Alexandre Coudray, Alberto De Iaco

After fertilization of the transcriptionally silent oocyte, expression from both parental chromosomes is launched through zygotic genome activation (ZGA), occurring in the mouse at the 2-cell (2C) stage. Among the first elements to be transcribed are the D ...

2019

Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

Cathrin Brisken, Melody Swartz, Witold Waldemar Kilarski, Csaba Ferenc László, Elena Menietti, Dania Al Labban

Stromal fibroblast senescence has been linked to ageing-associated cancer risk. However, density and proliferation of cancer-associated fibroblasts (CAFs) are frequently increased. Loss or downmodulation of the Notch effector CSL (also known as RBP-Jκ) in ...

Nature Publishing Group2015

An interplay between the p38 MAPK pathway and AUBPs regulates c-fos mRNA stability during mitogenic stimulation

Diego Chiappe, Tamara Tanos

Mitogen-activated protein kinase (MAPK) pathways constitute key regulatory elements linking extracellular stimuli to nuclear gene expression. Immediate-early responsive genes (IEGs) of the activator protein 1 (AP-1) family, such as fos, achieve peak expres ...

Portland Press Ltd2015

Metabolic expressivity of human genetic variants: NMR metabotyping of MEN1 pathogenic mutants

David Lyndon Emsley

Functional consequences of mutations in predisposition genes for familial cancer syndromes remain often elusive, especially when the corresponding gene products play pleiotropic functions and interact with numerous partners. Understanding the consequences ...

ELSEVIER SCIENCE BV2014

Pax6-dependent, but beta-catenin-independent, function of Bcl9 proteins in mouse lens development

Michel Aguet, Andreas Eduard Moor

Bcl9 and Bcl9l (Bcl9/9l) encode Wnt signaling components that mediate the interaction between beta-catenin and Pygopus (Pygo) via two evolutionarily conserved domains, HD1 and HD2, respectively. We generated mouse strains lacking these domains to probe the ...

Cold Spring Harbor Laboratory Press2014

MAP Kinase Phosphatase 1 (MKP-1/DUSP1) Is Neuroprotective in Huntington's Disease via Additive Effects of JNK and p38 Inhibition

Darlene Goldstein, Meredith Dixon

We previously demonstrated that sodium butyrate is neuroprotective in Huntington's disease (HD) mice and that this therapeutic effect is associated with increased expression of mitogen-activated protein kinase/dual-specificity phosphatase 1 (MKP-1/DUSP1). ...

Soc Neuroscience2013

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Transcription factor Jun

Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer

Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

DPPA2 and DPPA4 are necessary to establish a 2C‐like state in mouse embryonic stem cells

Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

An interplay between the p38 MAPK pathway and AUBPs regulates c-fos mRNA stability during mitogenic stimulation

Metabolic expressivity of human genetic variants: NMR metabotyping of MEN1 pathogenic mutants

Pax6-dependent, but beta-catenin-independent, function of Bcl9 proteins in mouse lens development

The Bcl-2/Bcl-XL inhibitor ABT-737 promotes death of retinoblastoma cancer cells

MAP Kinase Phosphatase 1 (MKP-1/DUSP1) Is Neuroprotective in Huntington's Disease via Additive Effects of JNK and p38 Inhibition

Graph Chatbot

Chattez avec Graph Search

Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

MAP Kinase Phosphatase 1 (MKP-1/DUSP1) Is Neuroprotective in Huntington's Disease via Additive Effects of JNK and p38 Inhibition

The Bcl-2/Bcl-XL inhibitor ABT-737 promotes death of retinoblastoma cancer cells

Pax6-dependent, but beta-catenin-independent, function of Bcl9 proteins in mouse lens development

An interplay between the p38 MAPK pathway and AUBPs regulates c-fos mRNA stability during mitogenic stimulation

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer

DPPA2 and DPPA4 are necessary to establish a 2C‐like state in mouse embryonic stem cells

Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder

Metabolic expressivity of human genetic variants: NMR metabotyping of MEN1 pathogenic mutants