Georges Wagnières

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Publications associées (166)

Negligible interaction of [Ru(Phen) 3 ] 2+ with human serum albumin makes it promising for a reliable in vivo assessment of the tissue oxygenation

Georges Wagnières, Veronika Huntosova

The interaction between a ruthenium - based water soluble oxygen probe ([Ru(Phen)3]2+, phen - phenanthroline) and human serum albumin (HSA) was investigated with the aim of describing the influence of HSA on the [Ru(Phen)3]2+ luminescence properties. Nowad ...

Elsevier2017

Time-resolved imaging of oxidative stress and cell/tissue oxygenation

Georges Wagnières, Veronika Huntosova

Springer2017

Intra-Arterial Drug and Light Delivery for Photodynamic Therapy Using Visudyne (R): Implication for Atherosclerotic Plaque Treatment

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Manish Jain

Photodynamic therapy (PDT), which is based on the activation of photosensitizers with light, can be used to reduce plaque burden. We hypothesized that intra-arterial photosensitizer administration and photo-activation will lead to high and rapid accumulati ...

2016

Measurement of pO2 by luminescence lifetime spectroscopy: A comparative study of the phototoxicity and sensitivity of [Ru(Phen)3]2+ and PdTCPP in vivo

Georges Wagnières, Emmanuel Louis Arthur Gerelli, Veronika Huntosova

Dysfunctions in tissue metabolism can be detected at early stages by oxygen partial pressure (pO(2)) measurement. The measurement of emission lifetimes offers very promising and non-invasive approach to estimate pO(2) in vivo. This study compares two exten ...

Wiley-V C H Verlag Gmbh2016

Effect of PpIX photoproducts formation on pO2 measurement by time-resolved delayed fluorescence spectroscopy of PpIX in solution and in vivo

Georges Wagnières, Emmanuel Louis Arthur Gerelli, Matthieu Philippe Emmanuel Zellweger, Veronika Huntosova

The measurement of Protoporphyrin IX delayed fluorescence lifetime is a minimally invasive method for monitoring the levels of oxygen in cells and tissues. The excitation of Protoporphyrin IX during this measurement can lead to the formation of photoproduc ...

Elsevier Science Sa2016

Review of the role played by the photosensitizer's photobleaching during photodynamic therapy

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

Photodynamic therapy (PDT) is based on the combined administration of photosensitizing drugs and light to treat a variety of malignant, pre-malignant and also non-malignant diseases. The reactive species resulting from the excitation of the photosensitizer ...

Natl Inst Optoelectronics2016

Optimization and characterization of the endogenous production of protoporphyrin IX in a yeast model

Georges Wagnières, Emmanuel Louis Arthur Gerelli, Jaroslava Joniová, Matthieu Philippe Emmanuel Zellweger

The availability of reproducible, convenient, and inexpensive model organisms able to generate predictable levels of endogenous porphyrins, including protoporphyrin IX (PpIX), is essential in photomedicine research. Saccharomyces cerevisiae produces endoge ...

SPIE Society of Photo-optical Instrumentation Engineers2016

Red and NIR light dosimetry in the human deep brain

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Blaise Lovisa

Photobiomodulation (PBM) appears promising to treat the hallmarks of Parkinson's Disease (PD) in cellular or animal models. We measured light propagation in different areas of PD-relevant deep brain tissue during transcranial, transsphenoidal illumination ...

Iop Publishing Ltd2015

Treatment of pleural malignancies by photo-induction combined to systemic chemotherapy: Proof of concept on rodent lung tumors and feasibility study on porcine chest cavities

Georges Wagnières, Michaël Bensimon, Elodie Debefve, Laurent Décosterd, Jean Yannis Perentes

Background: Low-dose, Visudyne (R)-mediated photodynamic therapy (photo-induction) was shown to selectively enhance tumor vessel transport causing increased uptake of systemically administered chemotherapy in various tumor types grown on rodent lungs. The ...

Wiley-Blackwell2015

Study of the influence of over-the-counter vitamin supplement intake on urine fluorescence to optimize cancer detection by fluorescence cystoscopy

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Carla Martoccia

Fluorescence cystoscopy (FC) efficiently enhances the detection and improves the therapeutic management of early bladder cancer. During an FC, about 150 ml of water is needed to inflate the bladder. The water is quickly diluted by urine which can be fluore ...

SPIE Society of Photo-optical Instrumentation Engineers2015

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