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Georges Wagnières

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A general framework for non-exponential delayed fluorescence and phosphorescence decay analysis, illustrated on Protoporphyrin IX

Georges Wagnières, Jaroslava Joniová, Emmanuel Louis Arthur Gerelli, Aurelien Stephen Arnaud Gregor

Delayed fluorescence (DF) is a long-lived luminescence process used in a variety of applications ranging from oxygen sensing in biological tissues to organic Light Emitting Diodes. In common cases, DF results from the deexcitation of the first excited trip ...

2020

Increase and homogenization of the endogenous production of protoporphyrin IX by photobiomodulation

Georges Wagnières, Jaroslava Joniová, Emmanuel Louis Arthur Gerelli

Photodynamic therapy (PDT) and/or photodetection (PDD) based on protoporphyrin IX (PpIX) are used in many medical fields. However, the endogenous production of PpIX in tissues after administration of its precursor, 5-aminolevulinic acid (ALA) or derivative ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Photoprotective effect of catechin during ALA-PDT

Georges Wagnières, Jaroslava Joniová

The production of reactive oxygen species (ROS) in normal tissues is associated with side effects of many cancer treatments. This is, in particular, the case for the skin photosensitization experienced by certain patients subjected to PDT based on a system ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Vascular-targeted low dose photodynamic therapy stabilizes tumor vessels by modulating pericyte contractility

Paul Joseph Dyson, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Tina Riedel

Vascular-targeted low-dose photodynamic therapy (L-PDT) was shown to improve chemotherapy distribution in malignant pleural tumors such as malignant pleural mesothelioma (MPM). However, the mechanisms triggered by L-PDT on the tumor vasculature are still d ...

WILEY2019

Measurements of the optical coefficients of the protoporphyrin IX endogenously producing yeast-based model in the visible and NIR

Georges Wagnières, Jaroslava Joniová, Emmanuel Louis Arthur Gerelli

SPIE Society of Photo-optical Instrumentation Engineers2018

Hypericin can cross barriers in the chicken's chorioallantoic membrane model when delivered in low-density lipoproteins

Georges Wagnières, Veronika Huntosova

Background: Low-density lipoproteins (LDL) were used as a natural drug delivery system for the transport of hypericin (Hyp) in the bloodstream of the chicken's chorioallantoic membrane model (CAM). Hyp was chosen as a model for hydrophobic drug used in pho ...

ELSEVIER SCIENCE BV2018

Modulation of the endogenous production of protoporphyrin IX in a yeast - based model organism

Georges Wagnières, Emmanuel Louis Arthur Gerelli, Jaroslava Joniová

The main aim of this study was to assess conditions at which simple yeast-based model organism produces maximal levels of protoporphyrin IX (PpIX) after an exogenous administration of its precursor, 5-aminolevulinic acid (ALA), and the ferrous-ion chelator ...

Spie-Int Soc Optical Engineering2017

Photodynamic therapy for the treatment of atherosclerotic plaque: Lost in translation?

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Manish Jain

Acute coronary syndrome is a life-threatening condition of utmost clinical importance, which, despite recent progress in the field, is still associated with high morbidity and mortality. Acute coronary syndrome results from a rupture or erosion of vulnerab ...

Wiley2017

Determination of the radiance of cylindrical light diffusers: design of a one-axis charge-coupled device camera-based goniometer setup

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Blaise Lovisa, Andreas Pitzschke, Jenny Bertholet

A one-axis charge-coupled device camera-based goniometer setup was developed to measure the three-dimensional radiance profile ( longitudinal, azimuthal, and polar) of cylindrical light diffusers in air and water. An algorithm was programmed to project the ...

SPIE Society of Photo-optical Instrumentation Engineers2017

In vivo measurement of the tissue oxygenation by time-resolved luminescence spectroscopy of protoporphyrin IX: Strategies to minimize artefacts associated with photoproducts

Georges Wagnières, Emmanuel Louis Arthur Gerelli, Veronika Huntosova

The determination of the oxygen partial pressure (pO(2)) in real time in living biological tissues is of high interest for numerous therapeutics, including photodynamic therapy (PDT) and radiotherapy. The minimally invasive and real-time measurement of the ...

Spie-Int Soc Optical Engineering2017

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A general framework for non-exponential delayed fluorescence and phosphorescence decay analysis, illustrated on Protoporphyrin IX

Georges Wagnières, Jaroslava Joniová, Emmanuel Louis Arthur Gerelli, Aurelien Stephen Arnaud Gregor

2020

Determination of the radiance of cylindrical light diffusers: design of a one-axis charge-coupled device camera-based goniometer setup

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Blaise Lovisa, Andreas Pitzschke, Jenny Bertholet

SPIE Society of Photo-optical Instrumentation Engineers2017

Measurements of the optical coefficients of the protoporphyrin IX endogenously producing yeast-based model in the visible and NIR

Georges Wagnières, Jaroslava Joniová, Emmanuel Louis Arthur Gerelli

SPIE Society of Photo-optical Instrumentation Engineers2018

In vivo measurement of the tissue oxygenation by time-resolved luminescence spectroscopy of protoporphyrin IX: Strategies to minimize artefacts associated with photoproducts

Georges Wagnières, Emmanuel Louis Arthur Gerelli, Veronika Huntosova

Spie-Int Soc Optical Engineering2017