Publications de Matthieu Philippe Emmanuel Zellweger

Optical Characterization of an Intra-Arterial Light and Drug Delivery System for Photodynamic Therapy of Atherosclerotic Plaque

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Andreas Pitzschke, Manish Jain, Ying Xiao

Although the versatility of photodynamic therapy (PDT) is well established, the technical aspects of light delivery systems vary significantly depending on the targeted organ. This article describes the optical properties of a light and drug delivery syste ...

2020

Vascular-targeted low dose photodynamic therapy stabilizes tumor vessels by modulating pericyte contractility

Paul Joseph Dyson, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Tina Riedel

Vascular-targeted low-dose photodynamic therapy (L-PDT) was shown to improve chemotherapy distribution in malignant pleural tumors such as malignant pleural mesothelioma (MPM). However, the mechanisms triggered by L-PDT on the tumor vasculature are still d ...

WILEY2019

Determination of the radiance of cylindrical light diffusers: design of a one-axis charge-coupled device camera-based goniometer setup

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Blaise Lovisa, Andreas Pitzschke, Jenny Bertholet

A one-axis charge-coupled device camera-based goniometer setup was developed to measure the three-dimensional radiance profile ( longitudinal, azimuthal, and polar) of cylindrical light diffusers in air and water. An algorithm was programmed to project the ...

SPIE Society of Photo-optical Instrumentation Engineers2017

Photodynamic therapy for the treatment of atherosclerotic plaque: Lost in translation?

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Manish Jain

Acute coronary syndrome is a life-threatening condition of utmost clinical importance, which, despite recent progress in the field, is still associated with high morbidity and mortality. Acute coronary syndrome results from a rupture or erosion of vulnerab ...

Wiley2017

Review of the role played by the photosensitizer's photobleaching during photodynamic therapy

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

Photodynamic therapy (PDT) is based on the combined administration of photosensitizing drugs and light to treat a variety of malignant, pre-malignant and also non-malignant diseases. The reactive species resulting from the excitation of the photosensitizer ...

Natl Inst Optoelectronics2016

Intra-Arterial Drug and Light Delivery for Photodynamic Therapy Using Visudyne (R): Implication for Atherosclerotic Plaque Treatment

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Manish Jain

Photodynamic therapy (PDT), which is based on the activation of photosensitizers with light, can be used to reduce plaque burden. We hypothesized that intra-arterial photosensitizer administration and photo-activation will lead to high and rapid accumulati ...

2016

Effect of PpIX photoproducts formation on pO2 measurement by time-resolved delayed fluorescence spectroscopy of PpIX in solution and in vivo

Georges Wagnières, Emmanuel Louis Arthur Gerelli, Matthieu Philippe Emmanuel Zellweger, Veronika Huntosova

The measurement of Protoporphyrin IX delayed fluorescence lifetime is a minimally invasive method for monitoring the levels of oxygen in cells and tissues. The excitation of Protoporphyrin IX during this measurement can lead to the formation of photoproduc ...

Elsevier Science Sa2016

Optimization and characterization of the endogenous production of protoporphyrin IX in a yeast model

Georges Wagnières, Emmanuel Louis Arthur Gerelli, Jaroslava Joniová, Matthieu Philippe Emmanuel Zellweger

The availability of reproducible, convenient, and inexpensive model organisms able to generate predictable levels of endogenous porphyrins, including protoporphyrin IX (PpIX), is essential in photomedicine research. Saccharomyces cerevisiae produces endoge ...

SPIE Society of Photo-optical Instrumentation Engineers2016

Red and NIR light dosimetry in the human deep brain

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Blaise Lovisa

Photobiomodulation (PBM) appears promising to treat the hallmarks of Parkinson's Disease (PD) in cellular or animal models. We measured light propagation in different areas of PD-relevant deep brain tissue during transcranial, transsphenoidal illumination ...

Iop Publishing Ltd2015

Optical properties of rabbit brain in the red and near-infrared: changes observed under in vivo, postmortem, frozen, and formalin-fixated conditions

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Blaise Lovisa, Andreas Pitzschke

The outcome of light-based therapeutic approaches depends on light propagation in biological tissues, which is governed by their optical properties. The objective of this study was to quantify optical properties of brain tissue in vivo and postmortem and a ...

SPIE Society of Photo-optical Instrumentation Engineers2015