Person
Matthieu Philippe Emmanuel Zellweger
This person is no longer with EPFL
Related publications (47)
Optical Characterization of an Intra-Arterial Light and Drug Delivery System for Photodynamic Therapy of Atherosclerotic Plaque
Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Andreas Pitzschke, Manish Jain, Ying Xiao
Although the versatility of photodynamic therapy (PDT) is well established, the technical aspects of light delivery systems vary significantly depending on the targeted organ. This article describes the optical properties of a light and drug delivery syste ...
2020Vascular-targeted low dose photodynamic therapy stabilizes tumor vessels by modulating pericyte contractility
Paul Joseph Dyson, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Tina Riedel
Vascular-targeted low-dose photodynamic therapy (L-PDT) was shown to improve chemotherapy distribution in malignant pleural tumors such as malignant pleural mesothelioma (MPM). However, the mechanisms triggered by L-PDT on the tumor vasculature are still d ...
WILEY2019Determination of the radiance of cylindrical light diffusers: design of a one-axis charge-coupled device camera-based goniometer setup
Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Blaise Lovisa, Andreas Pitzschke, Jenny Bertholet
A one-axis charge-coupled device camera-based goniometer setup was developed to measure the three-dimensional radiance profile ( longitudinal, azimuthal, and polar) of cylindrical light diffusers in air and water. An algorithm was programmed to project the ...
Spie-Soc Photo-Optical Instrumentation Engineers2017Photodynamic therapy for the treatment of atherosclerotic plaque: Lost in translation?
Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Manish Jain
Acute coronary syndrome is a life-threatening condition of utmost clinical importance, which, despite recent progress in the field, is still associated with high morbidity and mortality. Acute coronary syndrome results from a rupture or erosion of vulnerab ...
Wiley2017Interstitial fluid pressure: A novel biomarker to monitor photo-induced drug uptake in tumor and normal tissues.
Georges Wagnières, Michaël Bensimon, Matthieu Philippe Emmanuel Zellweger, Xi Wang, Jean Yannis Perentes
Low-dose photodynamic therapy PDT (photoinduction) can modulate tumor vessels and enhance the uptake of liposomal cisplatin (Lipoplatin®) in pleural malignancies. However, the photo-induction conditions must be tightly controlled as overtreatment shuts dow ...
Wiley2017Effect of PpIX photoproducts formation on pO2 measurement by time-resolved delayed fluorescence spectroscopy of PpIX in solution and in vivo
Georges Wagnières, Emmanuel Louis Arthur Gerelli, Matthieu Philippe Emmanuel Zellweger, Veronika Huntosova
The measurement of Protoporphyrin IX delayed fluorescence lifetime is a minimally invasive method for monitoring the levels of oxygen in cells and tissues. The excitation of Protoporphyrin IX during this measurement can lead to the formation of photoproduc ...
Elsevier Science Sa2016Optimization and characterization of the endogenous production of protoporphyrin IX in a yeast model
Georges Wagnières, Jaroslava Joniová, Emmanuel Louis Arthur Gerelli, Matthieu Philippe Emmanuel Zellweger
The availability of reproducible, convenient, and inexpensive model organisms able to generate predictable levels of endogenous porphyrins, including protoporphyrin IX (PpIX), is essential in photomedicine research. Saccharomyces cerevisiae produces endoge ...
Spie-Soc Photo-Optical Instrumentation Engineers2016Intra-Arterial Drug and Light Delivery for Photodynamic Therapy Using Visudyne (R): Implication for Atherosclerotic Plaque Treatment
Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Manish Jain
Photodynamic therapy (PDT), which is based on the activation of photosensitizers with light, can be used to reduce plaque burden. We hypothesized that intra-arterial photosensitizer administration and photo-activation will lead to high and rapid accumulati ...
2016Review of the role played by the photosensitizer's photobleaching during photodynamic therapy
Georges Wagnières, Matthieu Philippe Emmanuel Zellweger
Photodynamic therapy (PDT) is based on the combined administration of photosensitizing drugs and light to treat a variety of malignant, pre-malignant and also non-malignant diseases. The reactive species resulting from the excitation of the photosensitizer ...
Natl Inst Optoelectronics2016Study of the influence of over-the-counter vitamin supplement intake on urine fluorescence to optimize cancer detection by fluorescence cystoscopy
Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Carla Martoccia
Fluorescence cystoscopy (FC) efficiently enhances the detection and improves the therapeutic management of early bladder cancer. During an FC, about 150 ml of water is needed to inflate the bladder. The water is quickly diluted by urine which can be fluore ...
Spie-Soc Photo-Optical Instrumentation Engineers2015