Horst Pick

Publications associées (41)

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Insertion of T4-lysozyme (T4L) can be a useful tool for studying olfactory-related GPCRs

Horst Vogel, Horst Pick

2012

Bioanalytical reagent, method for production thereof, sensor platforms and detection methods based on use of said bioanalytical reagent

Horst Vogel, Horst Pick

The invention relates to various embodiments of a bioanalytical reagent with at least one vesicle, generated from a living cell, comprising at least one receptor, characterized in that a mechanism of signal transduction triggered by said receptor in the ce ...

2011

Recombinant expression and functional characterization of the mouse olfactory receptor mOR256-17 in mammalian cells

Horst Vogel, Horst Pick, Luigino Grasso, Thamani Dahoun

Olfactory receptors (ORs) constitute the largest family of sensory membrane proteins in mammals. They play a key role within the olfactory system in recognizing and discriminating a nearly unlimited number of structurally diverse odorous molecules. The mol ...

2011

The Mouse Eugenol Odorant Receptor: Structural and Functional Plasticity of a Broadly Tuned Odorant Binding Pocket

Horst Vogel, Horst Pick, Olivia Baud, Sylvain Etter

Molecular interactions of odorants with their olfactory receptors (ORs) are of central importance for the ability of the mammalian olfactory system to detect and discriminate a vast variety of odors with a limited set of receptors. How a particular OR bind ...

American Chemical Society2011

Bioanalytical procedure to detect membrane receptor activation

Horst Vogel, Horst Pick

The invention concerns a method for screening compound interaction with transmembrane receptors involved in cellular signal transduction, preferably with G protein coupled receptors, by adding the compound to be analyzed into a medium comprising native inv ...

2010

Dual activities of odorants on olfactory and nuclear hormone receptors

Horst Vogel, Horst Pick, Olivia Baud, Sylvain Etter, Ralf Schmauder

We have screened an odorant compound library and discovered molecules acting as chemical signals that specifically activate both G-protein-coupled olfactory receptors (ORs) on the cell surface of olfactory sensory neurons and the human nuclear estrogen rec ...

American Society for Biochemistry and Molecular Biology2009

Distribution Plasticity of the Human Estrogen Receptor α in Live Cells: Distinct Imaging of Consecutively Expressed Receptors

Horst Vogel, Horst Pick, Hanna Jankevics

Elsevier2007

Visualizing odorant receptor trafficking in living cells down to the single-molecule level

Horst Vogel, Horst Pick, Jean-Manuel Segura, Valérie Jacquier

Despite the importance of trafficking for regulating G protein-coupled receptor signaling, for many members of the seven transmembrane helix protein family, such as odorant receptors, little is known about this process in live cells. Here, the complete lif ...

National Academy of Sciences2006

Investigating cellular signaling reactions in single attoliter vesicles

Horst Vogel, Rudolf Hovius, Horst Pick, Erwin Ilegems

Understanding cellular signaling mediated by cell surface receptors is key to modern biomedical research and drug development. The discovery of a growing no. of potential mol. targets and therapeutic compds. requires downscaling and accelerated functional ...

2005

Diffusion-Time Distribution Analysis Reveals Characteristic Ligand-Dependent Interaction Patterns of Nuclear Receptors in Living Cells

Horst Vogel, Horst Pick, Paulina Izewska, Hanna Jankevics

Nuclear receptors initiate transcription, interact with regulatory proteins, and are influenced by hormones, drugs, and pollutants. Herein, we discover ligand-specific mobility patterns of human estrogen receptor-a (ER) in living cells using diffusion-time ...

2005

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