Thomas Lehnert

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Publications associées (52)

An automated microfluidic platform for reversible immobilization and imaging of C. elegans

Johan Auwerx, Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Laurent Mouchiroud, Marie-Pierre Meurville, Govindan Narayanan Krishnamani

2014

An automated microfluidic platform for long-term high-resolution imaging of C. elegans

Johan Auwerx, Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Laurent Mouchiroud, Marie-Pierre Meurville, Govindan Narayanan Krishnamani

We describe a microfluidic platform for the automated culture, treatment and long-term highresolution imaging of Caenorhabditis elegans nematodes under normal physiological conditions. Our device features: (i) a microfluidic design tailored for the isolati ...

2014

Fine-tuning of magnetic and microfluidic viscous forces for specific magnetic bead-based immunocomplex formation

Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Hüseyin Cumhur Tekin

We investigate the working principle of a novel type of microfluidic sandwich immunoassay, as used for the detection of biomarkers. The heterogeneous assay is based on the specific interactions between an array of functionalized superparamagnetic beads and ...

American Institute of Physics2013

Surface Microstructures on Planar Substrates and Textile Fibers Guide Neurite Outgrowth: A Scaffold Solution to Push Limits of Critical Nerve Defect Regeneration?

Thomas Lehnert, Li Yao

The treatment of critical size peripheral nerve defects represents one of the most serious problems in neurosurgery. If the gap size exceeds a certain limit, healing can't be achieved. Connection mismatching may further reduce the clinical success. The pre ...

Public Library Science2012

Magnetic particle dosing and size separation in a microfluidic channel

Martinus Gijs, Thomas Lehnert, Yves Moser, Rana Afshar Ghasemlouy

Separation of functional magnetic particles or magnetically labeled entities is a key feature for bioanalytical or biomedical applications and therefore also an important component of lab-on-a-chip devices for biological applications. We present a novel in ...

2011

Suspended SU-8 structures for monolithic microfluidic channels

Martinus Gijs, Thomas Lehnert, Sébastien Jiguet, Yves Moser, Riccardo Forti

SU-8 photoresist is commonly used in the field of microfabrication as structural material or for molding of microfluidic devices. One major limitation, however, is the difficulty to process partially freestanding SU-8 structures or monolithic closed caviti ...

Springer-Verlag2011

Three-Dimensional Magnetic Focusing of Superparamagnetic Beads for On-Chip Agglutination Assays

Martinus Gijs, Thomas Lehnert, Yves Moser, Rana Afshar Ghasemlouy

We present a new method for three-dimensional (3D) magnetic focusing of magnetic microparticles in a microfluidic system. On-chip magnetic particle manipulation in themicrochannel is achieved by a high-gradientmagnetic field generated by means of a microma ...

2011

Magneto-microfluidic three-dimensional focusing of magnetic particles

Martinus Gijs, Thomas Lehnert, Yves Moser, Rana Afshar Ghasemlouy

We present a method for magneto-microfluidic three-dimensional focusing of magnetic microparticles from a dense plug into a single streamline with longitudinal inter-particle spacing. Plug formation on-chip is induced by a high-gradient magnetic field gene ...

Amer Inst Physics, 2 Huntington Quadrangle, Ste 1No1 D, Melville, Ny 11747-4501 Usa2010

A quadrupolar magnetic actuation system for superparamagnetic particles

Martinus Gijs, Thomas Lehnert, Yves Moser

2009

Quadrupolar magnetic actuation of superparamagnetic particles for enhanced microfluidic perfusion

Martinus Gijs, Thomas Lehnert, Yves Moser

We report on the magnetic actuation of superparamagnetic particles in a microfluidic channel. The formation of a highly confined and dynamic plug of particles extending over the cross section of the microchannel is enabled by superposing a static and a tim ...

AIP American Institute of Physics2009

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Surface Microstructures on Planar Substrates and Textile Fibers Guide Neurite Outgrowth: A Scaffold Solution to Push Limits of Critical Nerve Defect Regeneration?

Thomas Lehnert, Li Yao

Public Library Science2012