Kai Johnsson

Publications associées (125)

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Sensors, methods and kits for detecting nicotinamide adenine dinucleotides

Kai Johnsson, Luc Reymond, Olivier Vincent Sallin

The invention relates to the in vitro and in cellulo detection of the cofactors nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Provided is a sensor molecule for fluorescence or luminescence-based detection o ...

2016

Acetylated tubulin is essential for touch sensation in mice

Kai Johnsson, Luc Reymond, Antonino Asaro

At its most fundamental level, touch sensation requires the translation of mechanical energy into mechanosensitive ion channel opening, thereby generating electro-chemical signals. Our understanding of this process, especially how the cytoskeleton influenc ...

Elife Sciences Publications Ltd2016

Fluorogenic Probes for Multicolor Imaging in Living Cells

Kai Johnsson, Luc Reymond, Grazvydas Lukinavicius, Olivier Vincent Sallin, Keitaro Umezawa

Here we present a far-red, silicon-rhodamine-based fluorophore (SiR700) for live-cell multicolor imaging. SiR700 has excitation and emission maxima at 690 nm and 715 nm, respectively. SiR700-based probes for F-actin, microtubules, lysosomes and SNAP-tag ar ...

American Chemical Society2016

Chemical Genetic Screen Identifies Natural Products that Modulate Centriole Number

Kai Johnsson, Pierre Gönczy, Michele Graciotti, Zhou Fang

Centrioles are microtubule-based organelles found in most eukaryotic cells and that are critical for the formation of cilia and flagella, as well as of centrosomes in animal cells. The number of centrioles must be strictly regulated in proliferating cells ...

Wiley-Blackwell2016

Sensor molecules and uses thereof

Kai Johnsson, Rudolf Griss, Alberto Schena

The invention generally relates to methods, reagents and devices for determining a concentration of an analyte in a sample. Provided is a proteinaceous sensor molecule for detecting an analyte of interest (A), comprising a signal generating moiety tethered ...

2015

NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro

Paul Joseph Dyson, Graham Knott, Mary-Claude Croisier-Coeytaux, Anders Meibom, Kai Johnsson, Stéphane Laurent Escrig

The in vitro inter-and intra-cellular distribution of an isotopically labelled ruthenium(II)-arene (RAPTA) anti-metastatic compound in human ovarian cancer cells was imaged using nano-scale secondary ion mass spectrometry (NanoSIMS). Ultra-high resolution ...

Royal Society of Chemistry2015

Tetrahydrobiopterin Biosynthesis as a Potential Target of the Kynurenine Pathway Metabolite Xanthurenic Acid

Kai Johnsson, Rudolf Hovius, Hirohito Haruki, Miriam Grønlund Pedersen

Tryptophan metabolites in the kynurenine pathway are up-regulated by pro-inflammatory cytokines or glucocorticoids, and are linked to anti-inflammatory and immunosuppressive activities. In addition, they are up-regulated in pathologies such as cancer, auto ...

Amer Soc Biochemistry Molecular Biology Inc2015

Genetically encoded biosensor for cell permeability of inhibitors of the p53-HDM2 interaction

Kai Johnsson, Silvia Scarabelli

Wiley-Blackwell2015

Imaging and manipulating proteins in live cells through covalent labeling

Kai Johnsson, Lin Xue, Julien Hiblot, Iuliia Karpenko

The past 20 years have witnessed the advent of numerous technologies to specifically and covalently label proteins in cellulo and in vivo with synthetic probes. These technologies range from self-labeling proteins tags to non-natural amino acids, and the q ...

Nature Publishing Group2015

Genetic targeting of chemical indicators in vivo

Kai Johnsson, Luc Reymond, Antonino Asaro

Fluorescent protein reporters have become the mainstay for tracing cellular circuitry in vivo but are limited in their versatility. Here we generated Cre-dependent reporter mice expressing the Snap-tag to target synthetic indicators to cells. Snap-tag labe ...

Nature Publishing Group2015

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NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro

Paul Joseph Dyson, Graham Knott, Mary-Claude Croisier-Coeytaux, Anders Meibom, Kai Johnsson, Stéphane Laurent Escrig

Royal Society of Chemistry2015