Kai Johnsson

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Publications associées (125)

NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro

Paul Joseph Dyson, Anders Meibom, Kai Johnsson, Graham Knott, Stéphane Laurent Escrig, Mary-Claude Croisier-Coeytaux

Royal Society of Chemistry2015

Modulating protein-protein interaction with a molecular tether

Kai Johnsson, Oliver Hantschel, Helen Rebecca Ostlund Farrants

Wiley-Blackwell2015

SiR–Hoechst is a far-red DNA stain for live-cell nanoscopy

Kai Johnsson, Luc Reymond, Alberto Schena, Grazvydas Lukinavicius

Cell-permeable DNA stains are popular markers in live-cell imaging. Currently used DNA stains for live-cell imaging are either toxic, require illumination with blue light or are not compatible with super-resolution microscopy, thereby limiting their utilit ...

Nature Research2015

A fluorogenic probe for SNAP-tagged plasma membrane proteins based on the solvatochromic molecule Nile Red

Kai Johnsson, Rudolf Hovius, Luc Reymond, Howard Riezman, Efthymia Prifti

A fluorogenic probe for plasma membrane proteins based on the dye Nile Red and SNAP-tag is introduced. It takes advantage of Nile Red, a solvatochromic molecule highly fluorescent in an apolar environment, such as cellular membranes, but almost dark in a p ...

Amer Chemical Soc2014

Protein tag-mediated conjugation of oligonucleotides to recombinant affinity binders for proximity ligation

Kai Johnsson

While antibodies currently play a dominant role as affinity reagents in biological research and for diagnostics, a broad range of recombinant proteins are emerging as promising alternative affinity reagents in detection assays and quantification. DNA-media ...

Elsevier2013

Labelling of Fusion Proteins with Synthetic Probes

Kai Johnsson, Alexandre Juillerat

The invention relates to new proteins called alkylcytosine transferases (ACTs) derived from O6-alkylguanine-DNA alkyltransferase, and to substrates for ACTs specifically transferring a label to these ACTs and to fusion proteins comprising these. The substr ...

2013

Sensing Acetylcholine and Anticholinesterase Compounds

Kai Johnsson, Alberto Schena

Acetylcholine is a key neurotransmitter, and anticholinesterase agents are essential compounds used as medical drugs, pesticides, and chemical warfare agents. A semisynthetic fluorescence-based probe for the direct, real-time detection of acetylcholine and ...

Wiley-Blackwell2013

Tetrahydrobiopterin Biosynthesis as an Off-Target of Sulfa Drugs

Kai Johnsson, Florence Pojer, Hirohito Haruki, Miriam Grønlund Pedersen, Katarzyna Irena Gorska

The introduction of sulfa drugs for the chemotherapy of bacterial infections in 1935 revolutionized medicine. Although their mechanism of action is understood, the molecular bases for most of their side effects remain obscure. Here, we report that sulfamet ...

American Association for the Advancement of Science2013

Identification of a small molecule with activity against drug-resistant and persistent tuberculosis (vol 110, pg E2510, 2013)

Kai Johnsson, Claudia Trefzer, Feng Wang, Yong Zhang, Jianing Wang

National Academy of Sciences2013

Selective Chemical Crosslinking Reveals a Cep57-Cep63-Cep152 Centrosomal Complex

Kai Johnsson, Pierre Gönczy, Luc Reymond, Grazvydas Lukinavicius, Keitaro Umezawa

The centrosome functions as the main microtubule-organizing center of animal cells and is crucial for several fundamental cellular processes [1]. Abnormalities in centrosome number and composition correlate with tumor progression [2, 3] and other diseases ...