Publications de Antonio Lopez | EPFL Graph Search

Optical projection tomography for rapid whole mouse brain imaging

Theo Lasser, Dimitri Nestor Alice Van De Ville, Jessica Sordet, Paul James Marchand, Arielle Louise Planchette, David Nguyen, Miguel Sison, Jérôme Extermann, Antonio Lopez, Marcin Antoni Sylwestrzak

In recent years, three-dimensional mesoscopic imaging has gained significant importance in life sciences for fundamental studies at the whole-organ level. In this manuscript, we present an optical projection tomography (OPT) method designed for imaging of ...

Optical Soc Amer2017

3D Time-lapse Imaging and Quantification of Mitochondrial Dynamics

Theo Lasser, Paul James Marchand, Jérôme Extermann, Miguel Sison, Antonio Lopez, Amir Jean Nahas

We present a 3D time-lapse imaging method for monitoring mitochondrial dynamics in living HeLa cells based on photothermal optical coherence microscopy and using novel surface functionalization of gold nanoparticles. The biocompatible protein-based biopoly ...

Nature Research2017

Compressed imaging by sparse random convolution

Theo Lasser, Aurélien Bourquard, Antonio Lopez

The theory of compressed sensing (CS) shows that signals can be acquired at sub-Nyquist rates if they are sufficiently sparse or compressible. Since many images bear this property, several acquisition models have been proposed for optical CS. An interestin ...

Optical Society of America2016

High-speed phase-shifting common-path quantitative phase imaging with a piezoelectric actuator

Theo Lasser, Antonio Lopez, Miguel Sison, Séverine Coquoz, Amir Jean Nahas

We present a phase-shifting quantitative phase imaging technique providing high temporal and spatial phase stability and high acquisition speed. A piezoelectric microfabricated phase modulator allows tunable modulation frequencies up to the kHz range. Afte ...

SPIE Society of Photo-optical Instrumentation Engineers2016

Combined Optical Coherence and Fluorescence Microscopy to assess dynamics and specificity of pancreatic beta-cell tracers

Theo Lasser, Anne Grapin-Botton, Arno Pino Bouwens, Christophe Pache, Daniel Pawel Szlag, Corinne Berclaz, Antonio Lopez

The identification of a beta-cell tracer is a major quest in diabetes research. However, since MRI, PET and SPECT cannot resolve individual islets, optical techniques are required to assess the specificity of these tracers. We propose to combine Optical Co ...

Nature Publishing Group2015

Real-time full field laser Doppler imaging

Theo Lasser, Marcel Leutenegger, Antonio Lopez, Erica Martin-Williams, Tyler Nerton Thacher

We present a full field laser Doppler imaging instrument, which enables real-time in vivo assessment of blood flow in dermal tissue and skin. This instrument monitors the blood perfusion in an area of about 50 cm² with 480 × 480 pixels per frame at a rate ...

2011

Method for displaying field e.g. tumor, of brain of human patient during surgery of brain, involves acquiring topography data representing topography of field, where output image is displayed based on topography data

Theo Lasser, Marcel Leutenegger, Antonio Lopez, Erica Martin-Williams

NOVELTY - The method involves illuminating a field (11) of brain (13) of a patient for acquiring an image sequence of the field. The field is illuminated after stimulating the patient for acquiring another image sequence. The image sequences are evaluated ...

2010

Object i.e. aneurysm, examining method for brain of patient, involves evaluating sequence of images by associating pixels with analysis image value depending on temporal changes of image values of pixels in specified frequency range

Theo Lasser, Marcel Leutenegger, Antonio Lopez, Erica Martin-Williams, Michael Friedrich

NOVELTY - The method involves illuminating an object i.e. aneurysm, with measuring light with wavelengths ranging from 790 nanometer to 820 nanometer, and recording a sequence of images (21, 22) i.e. white light image, of the illuminated object. The sequen ...

2009

See the Brain at Work—Intraoperative Laser Doppler Functional Brain Imaging

Michaël Unser, Theo Lasser, Marcel Leutenegger, Dimitri Nestor Alice Van De Ville, Rainer Leitgeb, Antonio Lopez, Erica Martin-Williams

During open brain surgery we acquire perfusion images non-invasively using laser Doppler imaging. The regions of brain activity show a distinct signal in response to stimulation providing intraoperative functional brain maps of remarkably strong contrast. ...

2009

Method for displaying field of brain of patient during brain surgery involves determining output image from analysis image values and displaying output image

Theo Lasser, Marcel Leutenegger, Antonio Lopez, Erica Martin-Williams

NOVELTY - The display method involves evaluating the sequence of images by: associating a first analysis image value to pixels in the first sequence of images to which pixels of same locations of the field (11) are imaged, respectively; associating a secon ...

2008