Publications de Niels Erik Lion

Red blood cells ageing markers: a multi-parametric analysis

Gerardo Turcatti, Niels Erik Lion, Benjamin Rappaz, David Crettaz, Michel Prudent, Manon Sandra Bardyn

Background. Red blood cells collected in citrate-phosphate-dextrose can be stored for up to 42 days at 4 degrees C in saline-adenine-glucose-mannitol additive solution. During this controlled, but nevertheless artificial, ex vivo ageing, red blood cells ac ...

Simti Servizi Srl2017

The antioxidant capacity of erythrocyte concentrates is increased during the first week of storage and correlated with the uric acid level

Hubert Girault, Niels Erik Lion, Andreas Stephan Lesch, Michel Prudent, Fernando Cortes Salazar, Sunny Isaïe Maye, Manon Sandra Bardyn

Background and Objectives: Red blood cells (RBCs) suffer from lesions during cold storage, depending in part on their ability to counterbalance oxidative stress by activating their antioxidant defence. The aim of this study was to monitor the antioxidant p ...

Wiley-Blackwell2017

Sensitive and fast identification of bacteria in blood samples by immunoaffinity mass spectrometry for quick BSI diagnosis

Hubert Girault, Horst Pick, Niels Erik Lion, Natalia Gasilova, Michel Prudent, Liang Qiao, Yingdi Zhu, Alexandra Bondarenko

Bloodstream infections rank among the most serious causes of morbidity and mortality in hospitalized patients, partly due to the long period (up to one week) required for clinical diagnosis. In this work, we have developed a sensitive method to quickly and ...

Royal Soc Chemistry2016

Dynamic Metabolic Flux Analysis of Stored Red Blood Cells

Michel Prudent, Niels Erik Lion, Frédéric Stauber

Wiley-Blackwell2016

The Antioxidant Defense System of Erythrocyte Concentrates is Increased during the First Week of Storage

Michel Prudent, Niels Erik Lion, Fernando Cortes Salazar, Michael Müller

Wiley-Blackwell2016

Molecular screening of cancer-derived exosomes by surface plasmon resonance spectroscopy

Horst Vogel, Niels Erik Lion, Davide Demurtas, Luigino Grasso, Romain Wyss, Michel Prudent, Ashwin Thampi, Lorenz Weidenauer

We report on a generic method to detect and iden- tify the molecular profile of exosomes either derived from cultured cell lines or isolated from biofluids. Exosomes are nanovesicles shed by cells into their microenvironment and carry the molecular identit ...

Springer Heidelberg2015

Loss of Protein Tyr-phosphorylation During in vitro Storage of Human Erythrocytes: Impact on RBC Morphology

Gerardo Turcatti, Niels Erik Lion, Benjamin Rappaz, Pierre Marquet, Michel Prudent

Wiley-Blackwell2014

Large scale inkjet-printing of carbon nanotubes electrodes for antioxidant assays in blood bags

Hubert Girault, Niels Erik Lion, Andreas Stephan Lesch, Fernando Cortes Salazar, Michel Prudent

Herein, we present the large scale fabrication of carbon nanotubes (CNT) electrodes supported on flexible polymeric sheets by subsequent multilayer inkjet printing of a silver layer for electrical connection, CNT layers as active electrode material and an ...

Elsevier2014

Dual-Channel Electrospray Microchip

Hubert Girault, Niels Erik Lion, Yu Lu, Fang Liu

A dual-channel electrospray microchip has been developed for electrospray ionization mass spectrometry (ESI-MS) where aqueous samples are mixed at the Taylor cone with an organic buffer. Due to the fast and effective mixing in the Taylor cone, the aqueous ...

2013

Electrochemical reactions and ionization processes

Hubert Girault, Niels Erik Lion, Liang Qiao, Michel Prudent, Hongyan Bi, Mélanie Abonnenc

Electrochemical or photo-electrochemical reactions in both electrospray ionization and laser desorption ionization are discussed stressing the role of the electrode reaction in influencing the ionization process. In particular, upon application of a high v ...

2010