Publications de Darlene Goldstein

Automatic module selection from several microarray gene expression studies

Anthony Christopher Davison, Darlene Goldstein, Alix Corinne Josiane Colette Zollinger

2018

Meta-analysis of incomplete microarray studies

Anthony Christopher Davison, Darlene Goldstein, Alix Corinne Josiane Colette Zollinger

Meta-analysis of microarray studies to produce an overall gene list is relatively straightforward when complete data are available. When some studies lack information, for example, having only a ranked list of genes instead of complete primary data, it is ...

Oxford University Press2015

MAP Kinase Phosphatase 1 (MKP-1/DUSP1) Is Neuroprotective in Huntington's Disease via Additive Effects of JNK and p38 Inhibition

Darlene Goldstein, Meredith Dixon

We previously demonstrated that sodium butyrate is neuroprotective in Huntington's disease (HD) mice and that this therapeutic effect is associated with increased expression of mitogen-activated protein kinase/dual-specificity phosphatase 1 (MKP-1/DUSP1). ...

Soc Neuroscience2013

Serum antiglycan antibody detection of nonmucinous ovarian cancers by using a printed glycan array

Darlene Goldstein

Epithelial ovarian cancer has the highest mortality rate among gynecological cancers. Altered glycosylation is associated with oncogenic transformation producing tumor-associated carbohydrate antigens. We investigated the potential of natural occurring ant ...

2012

Anti-glycan antibodies in epithelial ovarian cancer

Darlene Goldstein

Spandidos Publ Ltd2012

No benefit from combining HE4 and CA125 as ovarian tumor markers in a clinical setting

Darlene Goldstein

Objective. About 70% of epithelial ovarian cancer patients (EOC) are diagnosed at advanced stage with a five-year survival rate of only 30%. Whilst CA125 detects peritoneally-spread disease, it has limited sensitivity for early cancers, many of which are p ...

2011

Comparison of printed glycan array, suspension array and ELISA in the detection of human anti-glycan antibodies

Darlene Goldstein

Anti-glycan antibodies represent a vast and yet insufficiently investigated subpopulation of naturally occurring and adaptive antibodies in humans. Recently, a variety of glycan-based microarrays emerged, allowing high-throughput profiling of a large reper ...

2011

Environmental Enrichment Reduces Neuronal Intranuclear Inclusion Load But Has No Effect on Messenger RNA Expression in a Mouse Model of Huntington Disease

Darlene Goldstein

Huntington disease (HD) is a fatal neurodegenerative disease with no effective treatment. In the R6/1 mouse model of HD, environmental enrichment delays the neurologic phenotype onset and prevents cerebral volume loss by unknown molecular mechanisms. We ex ...

Lippincott, Williams & Wilkins2010

Curvature and Strength of Ni-YSZ Solid Oxide Half-cells after RedOx Treatments

Antonin Faes, Darlene Goldstein, Andreas Kaiser

One of the main drawbacks of anode-supported solid oxide fuel cell technology is the limited capability to withstand reduction and oxidation (“RedOx”) of the Ni phase. This study compares the effect of RedOx cycles on curvature and strength of half-cells, ...

American Soc Mechanical Engineers, Three Park Avenue, New York, Ny 10016-5990 Usa2010

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

Darlene Goldstein, Chenxu Zhao, Mauro Delorenzi, Li Zhang, Vlad Popovici, Jun Luo, Wen Luo, Wei Wang, Ying Liu, Jonathan Koh Boon Han

Gene expression data from microarrays are being applied to predict preclinical and clinical endpoints, but the reliability of these predictions has not been established. In the MAQC-II project, 36 independent teams analyzed six microarray data sets to gene ...

Nature Publishing Group2010