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Boris Hinz

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Publications associées (40)

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Triplet imaging of oxygen consumption during the contraction of a single smooth muscle cell (A7r5)

Dimitri Nestor Alice Van De Ville, Theo Lasser, Kai Johnsson, Marcel Leutenegger, Boris Hinz, Iwan Märki, Thiemo Spielmann, Aurélie Formey de Saint Louvent

The measurement of tissue and cell oxygenation is important for understanding cell metabolism. We have addressed this problem with a novel optical technique, called triplet imaging, that exploits oxygen-induced triplet lifetime changes and is compatible wi ...

Elsevier2010

Coated medical device and method of coating a medical device to reduce, fibrosis and capsule formation

Hicham Majd, Boris Hinz, Giorgio Pietramaggiori

Coating for a medical device comprising cell-adhesive proteins having the ability to reduce fibrous reaction, said coating being in the form of separate islets having an individual area which is less than 12 [mu]m2 and wherein the distance between the isle ...

2010

Myofibroblasts work best under stress

Boris Hinz, Pierre Jean Arnould Wipff

Myofibroblasts are reparative connective tissue cells that contribute to the reconstruction of injured tissue by secreting new extracellular matrix and by exerting high contractile force. Deregulation of these activities results in tissue contracture and d ...

Elsevier2009

Triplet State Imaging

Dimitri Nestor Alice Van De Ville, Theo Lasser, Boris Hinz, Iwan Märki, Thiemo Spielmann, Aurélie Formey de Saint Louvent

We present a functional imaging method based on triplet state kinetics. The triplet state of many known fluorophores shows a triplet lifetime typically in the order of ~10e-6 – 10e-3 s, 3-6 orders of magnitude longer than the associated fluorescence single ...

2009

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We present an imaging contrast based on triplet state life-time extracted from a series of images taken with modulated excitation schemes. This technique is validated by visualizing oxygen consumption dur- ing contraction of smooth muscle cells. ...

2009

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Strain devices with expandable polydimethylsiloxane (PDMS) culture membranes are frequently used to stretch cells in vitro, mimicking mechanically dynamic tissue environments. To immobilize cell-adhesive molecules to the otherwise non-adhesive PDMS substra ...

Elsevier2009

Triplet imaging by modulated excitation

Dimitri Nestor Alice Van De Ville, Theo Lasser, Kai Johnsson, Boris Hinz, Iwan Märki, Thiemo Spielmann, Aurélie Formey de Saint Louvent

A novel imaging method exploiting the photophysics of fluores- cent markers is presented, where the contrast depends on the triplet state kinetics, which are considerably slower than the sin- glet state kinetics. This makes it more sensitive to the microen ...

2009

Fibrogenic fibroblasts increase intercellular adhesion strength by reinforcing individual OB-cadherin bonds

Andrzej Kulik, Jean-Jacques Meister, Boris Hinz, Kyumin Lee, Philippe Pittet

We have previously shown that the switch from N-cadherin to OB-cadherin expression increases intercellular adhesion between fibroblasts during their transition from a migratory to a fibrogenic phenotype. Using atomic force microscopy we here show that part ...

2008

Inactivating mutations of the tumor-suppressor kinase gene LKB1 underlie Peutz-Jeghers syndrome (PJS), which is characterized by gastrointestinal hamartomatous polyps with a prominent smooth-muscle and stromal component. Recently, it was noted that PJS-typ ...

Company of Biologists2008

Integrins are crucial for the ability of cells to sense mechanical perturbations and to transmit intracellular stress to their environment. We here review the more recently discovered role of integrins in activating the pleiotrophic cytokine transforming g ...

Elsevier2008