Boris Hinz

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Related publications (34)

Myofibroblasts work best under stress

Boris Hinz, Pierre Jean Arnould Wipff

Myofibroblasts are reparative connective tissue cells that contribute to the reconstruction of injured tissue by secreting new extracellular matrix and by exerting high contractile force. Deregulation of these activities results in tissue contracture and d ...

Elsevier2009

The covalent attachment of adhesion molecules to silicone membranes for cell stretching applications

Jean-Jacques Meister, Hicham Majd, Lara Buscemi Estefanell, Boris Hinz, Pierre Jean Arnould Wipff

Strain devices with expandable polydimethylsiloxane (PDMS) culture membranes are frequently used to stretch cells in vitro, mimicking mechanically dynamic tissue environments. To immobilize cell-adhesive molecules to the otherwise non-adhesive PDMS substra ...

Elsevier2009

The effect of lactose-conjugated silk biomaterials on the development of fibrogenic fibroblasts

Boris Hinz

Surface properties of implanted biomaterials can cause fibrotic tissue reactions by stimulating differentiation of host fibroblasts into contractile myofibroblasts. Silk fibroin (SF) protein has been used as biomaterial in pure and blended form. however, i ...

Elsevier2008

Myofibroblast communication is controlled by intercellular mechanical coupling

Jean-Jacques Meister, Lysianne Follonier Castella, Boris Hinz, Sébastien Schaub

Neoformation of intercellular adherens junctions accompanies the differentiation of fibroblasts into contractile myofibroblasts, a key event during development of fibrosis and in wound healing. We have previously shown that intercellular mechanical couplin ...

Company of Biologists2008

Integrins and the activation of latent transforming growth factor beta1 - an intimate relationship

Boris Hinz, Pierre Jean Arnould Wipff

Integrins are crucial for the ability of cells to sense mechanical perturbations and to transmit intracellular stress to their environment. We here review the more recently discovered role of integrins in activating the pleiotrophic cytokine transforming g ...

Elsevier2008

Lkb1 is required for TGFβ-mediated myofibroblast differentiation

Boris Hinz, Pierre Jean Arnould Wipff

Inactivating mutations of the tumor-suppressor kinase gene LKB1 underlie Peutz-Jeghers syndrome (PJS), which is characterized by gastrointestinal hamartomatous polyps with a prominent smooth-muscle and stromal component. Recently, it was noted that PJS-typ ...

Company of Biologists2008

Fibrogenic fibroblasts increase intercellular adhesion strength by reinforcing individual OB-cadherin bonds

Andrzej Kulik, Jean-Jacques Meister, Boris Hinz, Kyumin Lee, Philippe Pittet

We have previously shown that the switch from N-cadherin to OB-cadherin expression increases intercellular adhesion between fibroblasts during their transition from a migratory to a fibrogenic phenotype. Using atomic force microscopy we here show that part ...

2008

A novel method of dynamic culture surface expansion improves mesenchymal stem cell proliferation and phenotype

Hicham Majd, Lara Buscemi Estefanell, Boris Hinz, Pierre Jean Arnould Wipff

Repeated passaging in conventional cell culture reduces pluripotency and proliferation capacity of human mesenchymal stem cells (MSC). We introduce an innovative cell culture method whereby the culture surface is dynamically enlarged during cell proliferat ...

2008

Grab, stick, pull and digest: The functional diversity of actin-associated matrix-adhesion structures: Workshop on Invadopodia, Podosomes and Focal Adhesions in Tissue Invasion

Boris Hinz

2008

The myofibroblast - friend or foe in regenerative medicine?

Boris Hinz

2008

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Grab, stick, pull and digest: The functional diversity of actin-associated matrix-adhesion structures: Workshop on Invadopodia, Podosomes and Focal Adhesions in Tissue Invasion

Boris Hinz

2008

The covalent attachment of adhesion molecules to silicone membranes for cell stretching applications

Jean-Jacques Meister, Hicham Majd, Lara Buscemi Estefanell, Boris Hinz, Pierre Jean Arnould Wipff

Elsevier2009