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Carl Petersen

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Cortical sensory processing across motivational states during goal-directed behavior

Carl Petersen, Matthieu Pierre Auffret, Georgios Foustoukos, Sami El-Boustani, Johannes Maria Mayrhofer, Maëlle Guyoton

Behavioral states can influence performance of goal-directed sensorimotor tasks. Yet, it is unclear how altered neuronal sensory representations in these states relate to task performance and learning. We trained water-restricted mice in a two-whisker disc ...

2022

3D Ultrastructure of Synaptic Inputs to Distinct GABAergic Neurons in the Mouse Primary Visual Cortex

Carl Petersen, Graham Knott, Jérôme Blanc, Catherine Maclachlan

Synapses are the fundamental elements of the brain's complicated neural networks. Although the ultrastructure of synapses has been extensively studied, the difference in how synaptic inputs are organized onto distinct neuronal types is not yet fully unders ...

OXFORD UNIV PRESS INC2021

Cell Type-Specific Membrane Potential Changes in Dorsolateral Striatum Accompanying Reward-Based Sensorimotor Learning

Carl Petersen, Sylvain Crochet, Tanya C Sippy

The striatum integrates sensorimotor and motivational signals, likely playing a key role in reward-based learning of goal-directed behavior. However, cell type-specific mechanisms underlying reinforcement learning remain to be precisely determined. Here, w ...

OXFORD UNIV PRESS2021

Cell-type-specific nicotinic input disinhibits mouse barrel cortex during active sensing

Carl Petersen, Sylvain Crochet, Célia Roxane Gasselin, Benoît Hohl

Fast synaptic transmission relies upon the activation of ionotropic receptors by neurotransmitter release to evoke postsynaptic potentials. Glutamate and GABA play dominant roles in driving highly dynamic activity in synaptically connected neuronal circuit ...

CELL PRESS2021

Neuronal Circuits In Barrel Cortex For Whisker Sensory Perception

Carl Petersen

The array of whiskers on the snout provides rodents with tactile sensory information relating to the size, shape and texture of objects in their immediate environment. Rodents can use their whiskers to detect stimuli, distinguish textures, locate objects a ...

AMER PHYSIOLOGICAL SOC2021

Toward Biophysical Mechanisms of Neocortical Computation after 50 Years of Barrel Cortex Research

Carl Petersen, Graham Knott, Felix Schürmann

2021

Rapid suppression and sustained activation of distinct cortical regions for a delayed sensory-triggered motor response

Wulfram Gerstner, Carl Petersen, Sylvain Crochet, Alireza Modirshanechi, Vahid Esmaeili, Georgios Foustoukos, Samuel Pavio Muscinelli, Yanqi Liu, Keita Tamura, Anastasiia Oryshchuk

The neuronal mechanisms generating a delayed motor response initiated by a sensory cue remain elusive. Here, we tracked the precise sequence of cortical activity in mice transforming a brief whisker stimulus into delayed licking using wide-field calcium im ...

2021

Somatostatin enhances visual processing and perception by suppressing excitatory inputs to parvalbumin-positive interneurons in V1

Carl Petersen, Graham Knott, Catherine Maclachlan, Seung-Hee Lee

Somatostatin (SST) is a neuropeptide expressed in a major subtype of GABAergic interneurons in the cortex. Despite abundant expression of SST and its receptors, their modulatory function in cortical processing remains unclear. Here, we found that SST appli ...

2020

Ultrastructural comparison of dendritic spine morphology preserved with cryo and chemical fixation

Carl Petersen, Graham Knott, Jérôme Blanc, Natalya Korogod

Previously, we showed that cryo fixation of adult mouse brain tissue gave a truer representation of brain ultrastructure in comparison with a standard chemical fixation method (Korogod et al., 2015). Extracellular space matched physiological measurements, ...

2020

Anatomically and functionally distinct thalamocortical inputs to primary and secondary mouse whisker somatosensory cortices

Carl Petersen, Georgios Foustoukos, Sami El-Boustani, Berat Semihcan Sermet

Subdivisions of mouse whisker somatosensory thalamus project to cortex in a region-specific and layer-specific manner. However, a clear anatomical dissection of these pathways and their functional properties during whisker sensation is lacking. Here, we us ...

Nature Publishing Group2020

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Somatostatin enhances visual processing and perception by suppressing excitatory inputs to parvalbumin-positive interneurons in V1

Carl Petersen, Graham Knott, Catherine Maclachlan, Seung-Hee Lee

2020

Neuronal Circuits In Barrel Cortex For Whisker Sensory Perception

Carl Petersen

AMER PHYSIOLOGICAL SOC2021

Toward Biophysical Mechanisms of Neocortical Computation after 50 Years of Barrel Cortex Research

Carl Petersen, Graham Knott, Felix Schürmann

2021

Anatomically and functionally distinct thalamocortical inputs to primary and secondary mouse whisker somatosensory cortices

Carl Petersen, Georgios Foustoukos, Sami El-Boustani, Berat Semihcan Sermet

Nature Publishing Group2020

Ultrastructural comparison of dendritic spine morphology preserved with cryo and chemical fixation

Carl Petersen, Graham Knott, Jérôme Blanc, Natalya Korogod

2020