Personne
Luca Dede'
Cette personne n’est plus à l’EPFL
Publications associées (50)
The role of computational methods in cardiovascular medicine: a narrative review
Alfio Quarteroni, Luca Dede', Christian Vergara, Stefano Pagani
Background and Objective: Computational models of the cardiovascular system allow for a detailed and quantitative investigation of both physiological and pathological conditions, thanks to their ability to combine clinical-possibly patient-specific-data wi ...
Ame Publishing Company2024Whole-heart electromechanical simulations using Latent Neural Ordinary Differential Equations
Alfio Quarteroni, Francesco Regazzoni, Luca Dede'
Cardiac digital twins provide a physics and physiology informed framework to deliver personalized medicine. However, high-fidelity multi-scale cardiac models remain a barrier to adoption due to their extensive computational costs. Artificial Intelligence-b ...
Nature Portfolio2024A mathematical model that integrates cardiac electrophysiology, mechanics, and fluid dynamics: Application to the human left heart
We propose a mathematical and numerical model for the simulation of the heart function that couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and includes reduced models for cardiac valves and the circulatory system. Our mod ...
WILEY2023lifex-cfd: An open-source computational fluid dynamics solver for cardiovascular applications
Alfio Quarteroni, Luca Dede', Marco Fedele
Computational fluid dynamics (CFD) is an important tool for the simulation of the cardiovascular function and dysfunction. Due to the complexity of the anatomy, the transitional regime of blood flow in the heart, and the strong mutual influence between the ...
Amsterdam2023Impact of atrial fibrillation on left atrium haemodynamics: A computational fluid dynamics study
We analyse the haemodynamics of the left atrium, highlighting differences between healthy individuals and patients affected by atrial fibrillation. The computational study is based on patient-specific geometries of the left atria to simulate blood flow dyn ...
PERGAMON-ELSEVIER SCIENCE LTD2022Data integration for the numerical simulation of cardiac electrophysiology
Alfio Quarteroni, Andrea Manzoni, Luca Dede', Stefano Pagani
The increasing availability of extensive and accurate clinical data is rapidly shaping cardiovascular care by improving the understanding of physiological and pathological mechanisms of the cardiovascular system and opening new frontiers in designing thera ...
WILEY2021A mathematical dashboard for the analysis of Italian COVID-19 epidemic data
Alfio Quarteroni, Luca Dede', Nicola Parolini
An analysis of the COVID-19 epidemic is proposed on the basis of the epiMOX dashboard (publicly accessible at ) that deals with data of the epidemic trends and outbreaks in Italy from late February 2020. Our analysis provides an immediate appreciation of t ...
WILEY2021An image-based computational hemodynamics study of the Systolic Anterior Motion of the mitral valve
Alfio Quarteroni, Luca Dede', Christian Vergara, Marco Fedele
Systolic Anterior Motion (SAM) of the mitral valve - often associated with Hypertrophic Obstructive Cardiomyopathy (HOCM) - is a cardiac pathology in which a functional subaortic stenosis is induced during systole by the mitral leaflets partially obstructi ...
PERGAMON-ELSEVIER SCIENCE LTD2020MATHICSE Technical Report : A complex blood flow patterns in an idealized left ventricle: a numerical study
Alfio Quarteroni, Luca Dede', Anna Tagliabue
In this paper, we study the blood flow dynamics in a three-dimensional (3D) idealized left ventricle of the human heart whose deformation is driven by muscle contraction and relaxation in coordination with the action of the mitral and aortic valves. We pro ...
MATHICSE2017MATHICSE Technical Report : Biomembrane modeling with Isogeometric Analysis
Alfio Quarteroni, Luca Dede', Andrea Bartezzaghi
We consider the numerical approximation of lipid biomembranes, including red blood cells, described through the Canham-Helfrich model, according to which the shape minimizes the bending energy under area and volume constraints. Energy minimization is perfo ...
MATHICSE2017