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Julien Racle

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Publications associées (18)

Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes

Florence Pojer, George Coukos, Kelvin Ka Ching Lau, Amédé Noredine Larabi, Julien Racle, David Gfeller, Marta Andreia Da Silva Perez, Alexandre Harari

CD4+T cells orchestrate the adaptive immune response against pathogens and cancer by recognizing epitopes presented on class II major histocompatibility complex (MHC-II) molecules. The high polymorphism of MHC-II genes represents an important hurdle toward ...
CELL PRESS2023

Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma

Bruno Emanuel Ferreira De Sousa Correia, George Coukos, Elisa Oricchio, Jessica Sordet, Natalya Katanayeva, Julien Racle, Sarah Wehrle, Elena Battistello, Stephanie Jocelyne Sungalee, Elie Charles Eugène Dheilly, Giovanni Ciriello, Marco Mina

Genomic alterations in cancer cells can influence the immune system to favor tumor growth. In non-Hodgkin lymphoma, physiological interactions between B cells and the germinal center microenvironment are coopted to sustain cancer cell proliferation. We fou ...
2020

The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases

Olivier Martin, Vassily Hatzimanikatis, Jacques Rougemont, Giovanna Ambrosini, Nicolas Jean Philippe Guex, Marion Leleu, Nadine Fournier, Krisztian Homicsko, Julien Dorier, Christian Iseli, Fabrice David, Maxime Jan, Sophie Barret, Philipp Bucher, Mauro Delorenzi, Julien Racle, David Gfeller, João Pedro de Matos Rodrigues, Thomas Junier, Niklaus Johner, René Dreos, Rouayda Cavin Perier, Omid Shahmirzadi, Romain Fernand Pietro Groux, Ray Marcel Marin Florez, Somi Reddy Majjigapu, Christophe Bovigny, Marco Pagni, Julien Delafontaine, Sunil Kumar, Delphine Yvette L Grun, Philippe Jacquet, Philippe Moret, Haleh Yasrebi, Daniel Federico Hernandez Gardiol, Samuel Neuenschwander, Heinz Stockinger, Sebastian Schmidt, Lucila Aimo, Yoann Mouscaz, Sara Benmohammed, Thierry Lombardot, Patrick Roelli, Benjamin Paccaud, Linda Dib, Ioannis Xenarios, Olivier Michielin, Amos Bairoch, Thierry Sengstag, Andreas Schmid, Frederic Burdet, Aline Dousse, Madeleine Suffiotti, Nicolas Salamin, Grégoire Rossier, Daniel Schmocker, Atul Sethi, Guillaume Keller, Felipe Aristides Simao Neto, Ni Ai, Leonore Wigger, Marie Ghraichy, Saumya Gupta, Rounak Vyas, Thomas Stricker

The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to t ...
Oxford University Press2016

Analysis of Translation Elongation Dynamics in the Context of an Escherichia coli Cell

Vassily Hatzimanikatis, Julien Racle, Joana Raquel Pinto Vieira

Understanding the mechanisms behind translation and its rate-limiting steps is crucial for both the development of drug targets and improvement of heterologous protein production with many biotechnological applications, such as in pharmaceutical and biofue ...
Elsevier2016

Analysis of Translation Elongation Dynamics in the Context of an Escherichia coli Cell

Vassily Hatzimanikatis, Julien Racle, Joana Raquel Pinto Vieira

Understanding the mechanisms behind translation and its rate-limiting steps is crucial for both the development of drug targets and improvement of heterologous protein production with many biotechnological applications, such as in pharmaceutical and biofue ...
Elsevier2016

Noise analysis of genome-scale protein synthesis using a discrete computational model of translation

Vassily Hatzimanikatis, Julien Racle, Adam Stefaniuk

Noise in genetic networks has been the subject of extensive experimental and computational studies. However, very few of these studies have considered noise properties using mechanistic models that account for the discrete movement of ribosomes and RNA pol ...
Amer Inst Physics2015

Mathematical models and computational methods for the analysis of genome-scale protein synthesis

Julien Racle

Proteins are a ubiquitous and indispensable element for every living organism, from simple bacteria to mammals. Already in the simplest organisms, there exist some thousands of different protein species that take up a great variety of structures, and thus ...
EPFL2014

Protein synthesis - computational modeling and experimental integration

Vassily Hatzimanikatis, Julien Racle

Proteins are among the central elements in every living cell as these ultimately determine how the cell functions. The protein abundances can be regulated at many levels, such as transcription, translation and degradation. As the complexity increases when ...
2014

A Novel Pulse-Chase SILAC Strategy Measures Changes in Protein Decay and Synthesis Rates Induced by Perturbation of Proteostasis with an Hsp90 Inhibitor

Vassily Hatzimanikatis, Julien Racle, Céline Hernández

Standard proteomics methods allow the relative quantitation of levels of thousands of proteins in two or more samples. While such methods are invaluable for defining the variations in protein concentrations which follow the perturbation of a biological sys ...
Public Library of Science2013

Dynamic Impacts of the Inhibition of the Molecular Chaperone Hsp90 on the T-Cell Proteome Have Implications for Anti-Cancer Therapy

Julien Racle, Céline Hernández

The molecular chaperone Hsp90-dependent proteome represents a complex protein network of critical biological and medical relevance. Known to associate with proteins with a broad variety of functions termed clients, Hsp90 maintains key essential and oncogen ...
Public Library of Science2013

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