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Julien Racle

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Publications associées (18)

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A Genome-Scale Integration and Analysis of Lactococcus lactis Translation Data

Vassily Hatzimanikatis, Julien Racle

Protein synthesis is a template polymerization process composed by three main steps: initiation, elongation, and termination. During translation, ribosomes are engaged into polysomes whose size is used for the quantitative characterization of translatome. ...

Public Library of Science2013

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Protein synthesis plays an important role in biological systems since its products, proteins and enzymes, constitute most of the molecular machinery required for cell regulation, growth and function in the tissue. Understanding the mechanisms of decoding a ...

2013

Computational analysis of the interplay between tRNA competitive behavior and decoding type on the modulation of translation elongation rate

Vassily Hatzimanikatis, Julien Racle, Joana Raquel Pinto Vieira

There has been much discussion in the literature regarding the determinants of ribosomal decoding speed during the mRNA translation process. Computational results based on mechanistic models for ribosomal kinetics have predicted a major role for near-cogna ...

2013

A computational framework for the design of optimal protein synthesis

Vassily Hatzimanikatis, Julien Racle, Jan Overney

Despite the establishment of design principles to optimize codon choice for heterologous expression vector design, the relationship between codon sequence and final protein yield remains poorly understood. In this work, we present a computational framework ...

Wiley-Blackwell2012

Stochastic noise in translation

Vassily Hatzimanikatis, Julien Racle, Adam Stefaniuk

Translation lies at the heart of every living organism, it is the process synthesizing the proteins, a main component in the cells. Earlier studies have considered protein synthesis as mainly initiation limited, modeling it as a first-order reaction with r ...

2011

Stochastic noise in translation

Vassily Hatzimanikatis, Julien Racle, Adam Stefaniuk

2011

Protein synthesis is one of the central elements in every living cell. For this process, mRNAs coding for genes are simultaneously competing for the same translation machinery (ribosomes and amino acids). But the ultimate determinants of cellular functions ...

2010

Protein synthesis is one of the central elements in every living cell. For this process, the mRNAs coding for genes are simultaneously competing for the same translation machinery, i.e. for the same ribosomes and the same protein building blocks, the amino ...

2010