Personne
Maria del Carmen Sandi Perez
Publications associées (230)
A new rat model of creatine transporter deficiency reveals behavioral disorder and altered brain metabolism
Maria del Carmen Sandi Perez, Cristina Ramona Cudalbu, Jocelin Grosse, Dunja Simicic
Creatine is an organic compound used as fast phosphate energy buffer to recycle ATP, important in tissues with high energy demand such as muscle or brain. Creatine is taken from the diet or endogenously synthetized by the enzymes AGAT and GAMT, and specifi ...
2021Long term effects of peripubertal stress on excitatory and inhibitory circuits in the prefrontal cortex of male and female mice
The impact of stressful events is especially important during early life, because certain cortical regions, especially the prefrontal cortex (PFC), are still developing. Consequently, aversive experiences that occur during the peripubertal period can cause ...
ELSEVIER SCIENCE INC2021Towards an Evolutionary Theory of Stress Responses
All organisms have a stress response system to cope with environmental threats, yet its precise form varies hugely within and across individuals, populations, and species. While the physiological mechanisms are increasingly understood, how stress responses ...
2021Differential Susceptibility to the Impact of the COVID-19 Pandemic on Working Memory, Empathy, and Perceived Stress: The Role of Cortisol and Resilience
There are important individual differences in adaptation and reactivity to stressful challenges. Being subjected to strict social confinement is a distressful psychological experience leading to reduced emotional well-being, but it is not known how it can ...
2021Title: "Labels Matter: Is it stress or is it Trauma?"
In neuroscience, the term 'Stress' has a negative connotation because of its potential to trigger or exacerbate psychopathologies. Yet in the face of exposure to stress, the more common reaction to stress is resilience, indicating that resilience is the ru ...
SPRINGERNATURE2021CAFS: Cost-Aware Features Selection Method for Multimodal Stress Monitoring on Wearable Devices
David Atienza Alonso, Maria del Carmen Sandi Perez, Adriana Arza Valdes, João Pedro de Matos Rodrigues, Niloofar Momeni
Objective: Today, stress monitoring on wearable devices is challenged by the tension between high-detection accuracy and battery lifetime driven by multimodal data acquisition and processing. Limited research has addressed the classification cost on multim ...
2021Programming effects of peripubertal stress on spatial learning
Maria del Carmen Sandi Perez, Stamatina Tzanoulinou, Cristina Marquez Vega
Exposure to adversity during early life can have profound influences on brain function and behavior later in life. The peripubertal period is emerging as an important time-window of susceptibility to stress, with substantial evidence documenting long-term ...
2020Astrocytic release of ATP through type 2 inositol 1,4,5‐trisphosphate receptor calcium signaling and social dominance behavior in mice
Maria del Carmen Sandi Perez, Jocelin Grosse, Marie-Isabelle Guillot de Suduiraut, Fiona Hollis, Eva Ramos Fernandez
Brain mitochondrial function is critical for numerous neuronal processes. We recently identified a link between brain energy and social dominance, where higher levels of mitochondrial function resulted in increased social competitive ability. The underlyin ...
2020Locomotion in virtual environments predicts cardiovascular responsiveness to subsequent stressful challenges
Maria del Carmen Sandi Perez, Nathalie Heidi Meyer, João Pedro de Matos Rodrigues, Stephan Streuber, Erik Hans Jakob Studer
Individuals differ in their physiological responsiveness to stressful challenges, and stress potentiates the development of many diseases. Heart rate variability (HRV), a measure of cardiac vagal break, is emerging as a strong index of physiological stress ...
2020Therapeutic potential of glutathione-enhancers in stress-related psychopathologies
Maria del Carmen Sandi Perez, Sarah Catherine Sonnay, Fiona Hollis, Pascal Steiner, Ioannis Zalachoras, Eva Ramos Fernandez, Laia Morato Fornaguera
The mammalian brain has high energy demands, which may become higher in response to environmental challenges such as psychogenic stress exposure. Therefore, efficient neutralization of reactive oxygen species that are produced as a by-product of ATP synthe ...
2020