Publications de Luigi Bonacina

Photoresponsive Nanocarriers Based on Lithium Niobate Nanoparticles for Harmonic Imaging and On-Demand Release of Anticancer Chemotherapeutics

Sandrine Gerber, Jérémy Vuilleumier, Adrian Stefan Gheata, Dario Diviani, Luigi Bonacina, Simon Kaiser

Nanoparticle-based drug delivery systems have the potential for increasing the efficiency of chemotherapeutics by enhancing the drug accumulation at specific target sites, therebyreducing adverse side effects and mitigating patient acquired resistance. In ...

2022

Gd3+-Functionalized Lithium Niobate Nanoparticles for Dual Multiphoton and Magnetic Resonance Bioimaging

Marinella Mazzanti, Sandrine Gerber, Anne-Sophie Chauvin, Katarzyna Pierzchala, Ileana Ozana Jelescu, Jérémy Vuilleumier, Raphaël Jovita De Matos, Laura Camille Louise Nicolle, Adrian Stefan Gheata, Dario Diviani

Harmonic nanoparticles (HNPs) have emerged as appealing exogenous probes for optical bioimaging due to their distinctive features such as long-term photostability and spectral flexibility, allowing multiphoton excitation in the classical (NIR-I) and extend ...

2022

Photocontrolled release of the anticancer drug chlorambucil with caged harmonic nanoparticles

Sandrine Gerber, Jean-Pierre Wolf, Jérémy Vuilleumier, Raphaël Jovita De Matos, Luigi Bonacina

While chemotherapy is one of the most used treatments in oncology, the systemic administration of chemotherapeutics generally results in undesired damages to healthy tissues and cells, side effects such as severe nausea and leukopenia, and reduced efficacy ...

Wiley-VHCA AG2020

Two-photon triggered photorelease of caged compounds from multifunctional harmonic nanoparticles

Sandrine Gerber, Laure Menin, Daniel Ortiz Trujillo, Jérémy Vuilleumier, Raphaël Jovita De Matos, Luigi Bonacina

The design of stimuli-responsive nanocarriers has raised much attention to achieve higher local concentration of therapeutics and mitigate the appearance of drug resistance. The combination of imaging properties and controlled photorelease of active molecu ...

2019

Publisher's Note: “Implications of short time scale dynamics on long time processes” (Struct. Dyn. 4, 061507 (2017)]

Majed Chergui, Ursula Röthlisberger, Swarnendu Bhattacharyya, Luigi Bonacina, Cédric Schmidt

2018

Multi-harmonic imaging in the second near-infrared window of nanoparticle-labeled stem cells as effective monitoring tool in tissue depth

Sandrine Gerber, Solène Marcelle Françoise Marie Passemard, Luigi Bonacina

In order to assess the therapeutic potential of cell-based strategies, it is of paramount importance to elaborate and validate new tools for monitoring the behavior of injected cells in terms of tissue dissemination and engraftment properties. Here, we app ...

American Chemical Society2017

Implications of short time scale dynamics on long time processes

Majed Chergui, Ursula Röthlisberger, Swarnendu Bhattacharyya, Siri Camee van Keulen, Jean-Pierre Wolf, Cédric Schmidt, Luigi Bonacina

2017

Cellular uptake and biocompatibility of bismuth ferrite harmonic advanced nanoparticles

Sandrine Gerber, Solène Marcelle Françoise Marie Passemard, Davide Städler, Jean-Pierre Wolf, Stephanie Hwu, Luigi Bonacina, Daniel Rytz

Bismuth Ferrite (BFO) nanoparticles (BFO-NP) display interesting optical (nonlinear response) and magnetic properties which make them amenable for bio-oriented diagnostic applications as intra- and extra membrane contrast agents. Due to the relatively rece ...

Elsevier2015

Functionalized bismuth ferrite harmonic nanoparticles for cancer cells labelling and imaging

Sandrine Gerber, Davide Städler, Solène Marcelle Françoise Marie Passemard, Luigi Bonacina, Giona Sonego

Bismuth ferrite (BFO) harmonic nanoparticles (NPs) display high nonlinear optical efficiency and excellent biocompatibility profile which make them attractive for the development of diagnostic applications as contrast agents. In this study, we present a ge ...

Springer Verlag2015

Simultaneous Multi-Harmonic Imaging of Nanoparticles in Tissues for Increased Selectivity

Sandrine Gerber, Davide Städler, Jean-Pierre Wolf, Solène Marcelle Françoise Marie Passemard, Luigi Bonacina, Sébastien Courvoisier

We investigate the use of Bismuth Ferrite (BFO) nanoparticles for tumor tissue labelling in combination with infrared multi-photon excitation at 1250 nm. We report the efficient and simultaneous generation of second and third harmonic by the nanoparticles. ...

Amer Chemical Soc2015