Publications de Christophe Danelon

A cytotoxic ruthenium tris(bipyridyl) complex that accumulates at plasma membranes

Michael Graetzel, Paul Joseph Dyson, Horst Vogel, Shaik Mohammed Zakeeruddin, Olivier Pierre Zava, Christophe Danelon

Wiley-Blackwell2009

Probing the function of ionotropic and G protein-coupled receptors in surface-confined membranes

Horst Vogel, Samuel Terrettaz, Christophe Danelon

Elsevier2008

Modulation of proton-induced current fluctuations in the human nicotinic acetylcholine receptor channel

Horst Vogel, Rudolf Hovius, Christophe Danelon, Jörg Grandl

The nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel that switches upon activation from a closed state to a full conducting state. We found that the mutation delta S268K, located at 12' position of the second transmembrane domain of t ...

2007

Cell Membranes Suspended Across Nanoaperture Arrays

Jürgen Brugger, Horst Vogel, Christian Santschi, Christophe Danelon, Jean-Baptiste Perez

The authors present a method for spreading large (> 100 mm2) cell membrane fragments across nanoapertures in planar supports. Electron-beam and focused-ion-beam lithog. were used to fabricate arrays of 50-600 nm diam. holes in free-standing silicon nitride ...

2006

Micro- and nanostructured devices for investigating biomolecular interactions

Jürgen Brugger, Horst Vogel, Christian Santschi, Christophe Danelon, Jean-Baptiste Perez, Christoph Schreiter

Cell membrane receptors and ion channels are essential in many different cellular processes. To analyse the activity of membrane proteins in vesicles and biological cells, we fabricated micro- nanostructured chips, enabling the application of electrophysio ...

2006

Fabrication and functionalization of nanochannels by electron-beam-induced silicon oxide deposition

Jürgen Brugger, Horst Vogel, Christian Santschi, Christophe Danelon

We report on the fabrication and electrical characterization of functionalized solid-state nanopores in low stress silicon nitride membranes. First, a pore of approximately 50 nm diameter was drilled using a focused ion beam technique, followed by the loca ...

2006

Multifunctional Lipid/Quantum-Dots Hybrid Nanocontainers for Controlled Targeting of Live Cells

Horst Vogel, Pierre-Yves Bolinger, Davide Demurtas, Christophe Danelon, Paulina Izewska, Jacques Dubochet, Gopakumar Gopalakrishnan

In this communication, we report on an interesting observation of wide-ranging potential for cellular imaging and manipulation: Hydrophobic QDs can be easily incorporated into the bilayer membrane of lipid vesicles. Such lipid/QD nanocontainer hybrid vesic ...

Wiley-VCH Verlag GmbH2006

Functional asymmetry of transmembrane segments in nicotinic acetylcholine receptors

Horst Vogel, Rudolf Hovius, Christophe Danelon, Jörg Grandl

Nicotinic acetylcholine receptors are heteropentameric ion channels that open upon activation to a single conducting state. The second transmembrane segments of each subunit were identified as channel-forming elements, but their respective contribution in ...

2006