Publications de Benoît Schaller

Genetic Polymorphism Associated Prefrontal Glutathione and Its Coupling With Brain Glutamate and Peripheral Redox Status in Early Psychosis

Rolf Gruetter, Lijing Xin, Benoît Schaller, Kim Do, Huanxiang Lu

BACKGROUND: Oxidative stress and glutathione (GSH) metabolism dysregulation has been implicated in the pathophysiology of schizophrenia. GAG-trinucleotide repeat (TNR) polymorphisms in the glutamate-cysteine ligase catalytic gene (GCLC), the rate-limiting ...

Oxford University Press2016

Fast low-specific absorption rate B0-mapping along projections at high field using two-dimensional radiofrequency pulses

Rolf Gruetter, Daniel Gallichan, Benoît Schaller, Olivier Benoit Thomas Reynaud

Purpose At 7 Tesla (T), conventional static field (B0) projection mapping techniques, e.g., FASTMAP, FASTESTMAP, lead to elevated specific absorption rates (SAR), requiring longer total acquisition times (TA). In this work, the series of adiabatic pulses n ...

Wiley-Blackwell2015

Are glutamate and lactate increases ubiquitous to physiological activation? A 1H functional MR spectroscopy study during motor activation in human brain at 7Tesla

Rolf Gruetter, Lijing Xin, Benoît Schaller

Recent studies at high field (7 Tesla) have reported small metabolite changes, in particular lactate and glutamate (below 0.3 μmol/g) during visual stimulation. These studies have been limited to the visual cortex because of its high energy metabolism and ...

Elsevier2014

Quantification of the neurochemical profile using simulated macromolecule resonances at 3 T

Rolf Gruetter, Lijing Xin, Cristina Ramona Cudalbu, Benoît Schaller

The broad resonances underlying the entire (1) H NMR spectrum of the brain, ascribed to macromolecules, can influence metabolite quantification. At the intermediate field strength of 3 T, distinct approaches for the determination of the macromolecule signa ...

Wiley-Blackwell2013

Net increase of lactate and glutamate concentration in activated human visual cortex detected with magnetic resonance spectroscopy at 7 tesla

Rolf Gruetter, Lijing Xin, Nicolas Kunz, Benoît Schaller

After the landmark studies reporting changes in the cerebral metabolic rate of glucose (CMR(Glc) ) in excess of those in oxygen (CMR(O2) ) during physiological stimulation, several studies have examined the fate of the extra carbon taken up by the brain, r ...

Wiley-Blackwell2013

In Vivo Magnetic Resonance Spectroscopy (MRS) of the Activated Human Brain at 7T

Benoît Schaller

The principal aim of this thesis was to investigate human brain energy metabolism during physiological activation using proton (1H) magnetic resonance spectroscopy (MRS) at 7 Tesla (T). High magnetic fields (≥ 7 T) provide several advantages in human brain ...

EPFL2013

Proton T(1) relaxation times of metabolites in human occipital white and gray matter at 7 T

Rolf Gruetter, Lijing Xin, Benoît Schaller, Huanxiang Lu

Proton T(1) relaxation times of metabolites in the human brain have not previously been published at 7 T. In this study, T(1) values of CH(3) and CH(2) group of N-acetylaspartate and total creatine as well as nine other brain metabolites were measured in o ...

Wiley-Blackwell2013

Proton T1 relaxation times of metabolites in human occipital white matter and grey matter at 7T

Rolf Gruetter, Lijing Xin, Benoît Schaller

2012

QUANTIFICATION DIFFERENCES OF 1H SPECTRA IN HUMAN BRAIN AT 3 TESLA USING THE ACQUIRED MACROMOLECULE BASELINE OR THE BUILT-IN LCMODEL SPLINE BASELINE

Rolf Gruetter, Benoît Schaller, Xin Liu

2012

INFLUENCE OF TISSUE SPECIFIC MACROMOLECULE BASELINE ON THE METABOLITE QUANTIFICATION IN HUMAN BRAIN AT 7 TESLA

Rolf Gruetter, Lijing Xin, Benoît Schaller

2012