Publications de Marie Schaer | EPFL Graph Search

Structural control energy of resting-state functional brain states reveals less cost-effective brain dynamics in psychosis vulnerability

Dimitri Nestor Alice Van De Ville, Marie Schaer

How the brain's white-matter anatomy constrains brain activity is an open question that might give insights into the mechanisms that underlie mental disorders such as schizophrenia. Chromosome 22q11.2 deletion syndrome (22q11DS) is a neurodevelopmental dis ...

Wiley2021

Identifying neurodevelopmental anomalies of white matter microstructure associated with high risk for psychosis in 22q11.2DS

Maude Schneider, Daniela Maria Zöller, Marie Schaer, Maria Carmela Padula

Disruptions of white matter microstructure have been widely reported in schizophrenia. However, the emergence of these alterations during preclinical stages remains poorly understood. 22q11.2 Deletion Syndrome (22q11.2DS) represents a unique model to study ...

SPRINGERNATURE2020

Dynamic spatiotemporal patterns of brain connectivity reorganize across development

Alessandra Griffa, Patric Hagmann, Marie Schaer, Emeline Mullier

Late human development is characterized by the maturation of high-level functional processes, which rely on reshaping of white matter connections, as well as synaptic density. However, the relationship between the whole-brain dynamics and the underlying wh ...

MIT PRESS2020

Pituitary dysmaturation affects psychopathology and neurodevelopment in 22q11.2 Deletion Syndrome

Dimitri Nestor Alice Van De Ville, Maria del Carmen Sandi Perez, Maude Schneider, Marie Schaer, Daniela Maria Zöller, Maëlle Chambaz

Background 22q11.2 Deletion Syndrome (22q11DS) confers strongly increased genetic risk for multiple psychiatric disorders. Similarly to the general population, rates of psychiatric comorbidity suggest that common disease mechanisms are shared across dimens ...

2020

Large-Scale Brain Network Dynamics Provide a Measure of Psychosis and Anxiety in 22q11.2 Deletion Syndrome Daniela

Dimitri Nestor Alice Van De Ville, Marie Schaer, Fikret Isik Karahanoglu, Maria Carmela Padula

BACKGROUND: Prodromal positive psychotic symptoms and anxiety are two strong risk factors for schizophrenia in 22q11.2 deletion syndrome (22q11DS). The analysis of large-scale brain network dynamics during rest is promising to investigate aberrant brain fu ...

ELSEVIER2019

Robust Recovery of Temporal Overlap Between Network Activity Using Transient-Informed Spatio-Temporal Regression

Dimitri Nestor Alice Van De Ville, Thomas William Arthur Bolton, Marie Schaer, Fikret Isik Karahanoglu, Daniela Maria Zöller

Functional magnetic resonance imaging is a non-invasive tomographic imaging modality that has provided insights into system-level brain function. New analysis methods are emerging to study the dynamic behavior of brain activity. The innovation-driven co-ac ...

Institute of Electrical and Electronics Engineers2019

Cortical Dysconnectivity Measured by Structural Covariance Is Associated With the Presence of Psychotic Symptoms in 22q11.2 Deletion Syndrome

Dimitri Nestor Alice Van De Ville, Maude Schneider, Marie Schaer, Maria Carmela Padula

BACKGROUND: 22q11.2 deletion syndrome (22q11DS) is the third-largest known genetic risk factor for the development of psychosis. Dysconnectivity has consistently been implicated in the physiopathology of psychosis. Structural covariance of cortical morphol ...

2018

Cortical morphology development in patients with 22q11.2 deletion syndrome at ultra-high risk of psychosis

Maude Schneider, Marie Schaer, Daniela Maria Zöller, Maria Carmela Padula

Background. Patients with 22q11.2 deletion syndrome (22q11DS) present a high risk of developing psychosis. While clinical and cognitive predictors for the conversion towards a full-blown psychotic disorder are well defined and largely used in practice, neu ...

CAMBRIDGE UNIV PRESS2018

Disentangling resting-state BOLD variability and PCC functional connectivity in 22q11.2 deletion syndrome

Dimitri Nestor Alice Van De Ville, Marie Schaer, Daniela Maria Zöller, Maria Carmela Padula

Although often ignored in fMRI studies, moment-to-moment variability of blood oxygenation level dependent (BOLD) signals reveals important information about brain function. Indeed, higher brain signal variability has been associated with better cognitive p ...

Elsevier2017

An affected core drives network integration deficits of the structural connectome in 22q11.2 deletion syndrome

Alessandra Griffa, Patric Hagmann, Marie Schaer, Frantisek Vasa

Chromosome 22q11.2 deletion syndrome (22q11DS) is a genetic disease known to lead to cerebral structural alterations, which we study using the framework of the macroscopic white-matter connectome. We create weighted connectomes of 44 patients with 22q11DS ...

Elsevier Sci Ltd2016