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Ruud van Heeswijk

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Publications associées (17)

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The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo C-13 MRS studies using labeled substrates enhanced vi ...

2010

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We have recently shown that at isotopic steady state C-13 NMR can provide a direct measurement of glycogen concentration changes, but that the turnover of glycogen was not accessible with this protocol. The aim of the present study was to design, implement ...

Wiley-Blackwell2010

In vivo magnetic resonance studies of glycogen and hyperpolarized lithium in the rat brain

Ruud van Heeswijk

Nuclear magnetic resonance (NMR) is used for a large array of applications, ranging from chemical characterization to oil drilling to medical imaging. In these fields NMR is used as an investigational tool, but new techniques and applications are continuou ...

EPFL2009

Hyperpolarized Lithium-6 as a Sensor of Nanomolar Contrast Agents

Rolf Gruetter, Cristina Ramona Cudalbu, Arnaud Comment, Sami Jannin, Ruud van Heeswijk, Jacques Van Der Klink, Chiara Perazzolo, Fiodar Kurdzesau

Lithium is widely used in psychotherapy. The Li-6 isotope has a long intrinsic longitudinal relaxation time T-1 on the order of minutes, making it an ideal candidate for hyperpolarization experiments. In the present study we demonstrated that lithium-6 can ...

Wiley-Blackwell2009

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New low-temperature inserts compatible with an existing hyperpolarizer were developed to dynamically polarize nuclei in large samples. The performance of the system was tested on 8 ml glassy frozen solutions containing 13C-labeled molecules and doped with ...

2008

Non-invasive quantification of brain glycogen absolute concentration

Rolf Gruetter, Lijing Xin, Hongxia Lei, Ruud van Heeswijk, Hanne Frenkel, Sabrina Laus

The only currently available method to measure brain glycogen in vivo is C-13 NMR spectroscopy. Incorporation of C-13-labeled glucose (Glc) is necessary to allow glycogen measurement, but might be affected by turnover changes. Our aim was to measure glycog ...

Wiley-Blackwell2008

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The relaxivity of commercially available gadolinium (Gd)-based contrast agents was studied for X-nuclei resonances with long intrinsic relaxation times ranging from 6 s to several hundred seconds. Omniscan in pure 13C formic acid had a relaxivity of 2.9 mM ...

Elsevier2007