Publications de Fiodar Kurdzesau

Feasibility of in vivo N-15 MRS detection of hyperpolarized N-15 labeled choline in rats

Rolf Gruetter, Cristina Ramona Cudalbu, Arnaud Comment, Sami Jannin, Ruud van Heeswijk, Fiodar Kurdzesau

The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo C-13 MRS studies using labeled substrates enhanced vi ...

2010

Some methods of dynamic nuclear polarization for use in metabolic imaging

Fiodar Kurdzesau

It has been suggested already more than 60 years ago to use polarized nuclei in particle scattering experiments1, but only with the discovery of the solid effect dynamic nuclear polarization process2 the realisation of polarized solid targets became possib ...

EPFL2009

Hyperpolarized Lithium-6 as a Sensor of Nanomolar Contrast Agents

Rolf Gruetter, Cristina Ramona Cudalbu, Arnaud Comment, Sami Jannin, Ruud van Heeswijk, Jacques Van Der Klink, Chiara Perazzolo, Fiodar Kurdzesau

Lithium is widely used in psychotherapy. The Li-6 isotope has a long intrinsic longitudinal relaxation time T-1 on the order of minutes, making it an ideal candidate for hyperpolarization experiments. In the present study we demonstrated that lithium-6 can ...

Wiley-Blackwell2009

Dynamic nuclear polarization of small labelled molecules in frozen water-alcohol solutions

Arnaud Comment, Sami Jannin, Jacques Van Der Klink, Fiodar Kurdzesau

In recent years methods of creating 'hyperpolarized' substances have gained considerable attention in biomedical magnetic resonance and dynamic nuclear polarization (DNP) is one of the most promising, especially for imaging applications. Here we present re ...

2008

Producing over 100 ml of highly concentrated hyperpolarized solution by means of dissolution DNP

Arnaud Comment, Sami Jannin, Ruud van Heeswijk, Jacques Van Der Klink, Fiodar Kurdzesau

New low-temperature inserts compatible with an existing hyperpolarizer were developed to dynamically polarize nuclei in large samples. The performance of the system was tested on 8 ml glassy frozen solutions containing 13C-labeled molecules and doped with ...

Academic Press Inc - Elsevier Science2008

A 140 GHz prepolarizer for dissolution dynamic nuclear polarization

Arnaud Comment, Sami Jannin, Jacques Van Der Klink, Fiodar Kurdzesau

Apart from their very classical use to build polarized targets for particle physics, the methods of dynamic nuclear polarization (DNP) have more recently found application for sensitivity enhancement in high-resolution NMR, both in the solid and in the liq ...

2008

Principles of operation of a DNP prepolarizer coupled to a rodent MRI scanner

Rolf Gruetter, Arnaud Comment, Sami Jannin, Jacques Van Der Klink, Fiodar Kurdzesau

A dynamic nuclear polarization prepolarizer was developed and coupled to a 9.4 T rodent magnetic resonance imaging scanner in order to perform in vivo hyperpolarization experiments. In the present paper, emphasis is put on methods and hardware performance ...

2008

In Vivo Detection of Hyperpolarized 15N Choline in the Rat

Rolf Gruetter, Cristina Ramona Cudalbu, Arnaud Comment, Sami Jannin, Ruud van Heeswijk, Chiara Perazzolo, Fiodar Kurdzesau

2008

Design and performance of a DNP prepolarizer coupled to a rodent MRI scanner

Rolf Gruetter, Arnaud Comment, Sami Jannin, Jacques Van Der Klink, Fiodar Kurdzesau

For most of the last forty years, the techniques of Dynamic Nuclear Polarization (DNP) have been confined to particle-physics laboratories building polarized targets, but recently it has been shown that samples similar to a solid target can be transformed ...

2007