Publications de Adrian Schmid | EPFL Graph Search

Organohalide respiration: breakthrough towards the elucidation of the electron-accepting moiety of the respiratory chain

Christof Holliger, Julien Maillard, Adrian Schmid, Lorenzo Cimmino

Background Organohalide respiration (OHR) is a bacterial anaerobic process in which chlorinated compound, e.g. tetrachloroethene (PCE), is used as terminal electron acceptors. Dehalobacter restrictus PER-K23, a paradigmatic organohalide-respiring bacterium ...

2021

Absolute quantification of pceABCT gene products and characterization of the membrane protein complex responsible for the reduction of tetrachloroethene in Dehalobacter restrictus

Christof Holliger, Julien Maillard, Adrian Schmid, Lorenzo Cimmino

The pceABCT gene cluster from Dehalobacter restrictus is one model system for tetrachloroethene (PCE) respiration. In the present study we aim to decipher the stoichiometry of the pceABCT gene products and the composition of PceA-containing membrane-bound ...

2021

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Organohalide respiration (OHR) is a bacterial anaerobic respiratory process in which halogenated compounds are used as terminal electron acceptors. Desulfitobacterium and Dehalobacter, paradigmatic organohalide-respiring bacteria (OHRB), harbour the pceABC ...

2019

ANAEROBIC BIODEGRADATION OF ORGANOHALIDE POLLUTANTS: A CRUCIAL STEP TOWARDS THE ELUCIDATION OF PROTEINS INVOLVED

Christof Holliger, Julien Maillard, Adrian Schmid, Lorenzo Cimmino

Halogenated organic compounds (so-called organohalides) represent one of the major class of groundwater pollutants. The exploration of how organohalides are used as energy source is important in terms of ecosystem remediation but is also essential for the ...

2019

Anaerobic Biodegradation of organohalide pollutants: a crucial step towards the elucidation of proteins involved

Christof Holliger, Julien Maillard, Adrian Schmid, Lorenzo Cimmino

Halogenated organic compounds (so-called organohalides) represent one of the major class of groundwater pollutants. The exploration of how organohalides are used as energy source is important in terms of ecosystem remediation but is also essential for the ...

2019

Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity

Johan Auwerx, Davide D'Amico, Adrian Schmid, Norman Lionel Moullan, Vincenzo Sorrentino, Hongbo Zhang, Francesca Potenza, Solene Rietsch

Alzheimer's disease is a common and devastating disease characterized by aggregation of the amyloid-beta peptide. However, we know relatively little about the underlying molecular mechanisms or how to treat patients with Alzheimer's disease. Here we provid ...

Nature Publishing Group2017

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Amyloid-beta (A beta) peptide oligomerization plays a central role in the pathogenesis of Alzheimer's disease (AD), and A beta oligomers are collectively considered an appealing therapeutic target for the treatment of AD. However, the molecular mechanisms ...

Elsevier Science Inc2016

Lipidomics, which focuses on the global study of molecular lipids in biological systems, has been driven tremendously by technical advances in mass spectrometry (MS) instrumentation, particularly high-resolution MS. This requires powerful computational too ...

Elsevier2016

Flagellar membranes are rich in raft-forming phospholipids

Adrian Schmid

The observation that the membranes of flagella are enriched in sterols and sphingolipids has led to the hypothesis that flagella might be enriched in raft-forming lipids. However, a detailed lipidomic analysis of flagellar membranes is not available. Novel ...

Company Of Biologists Ltd2015

Absolute quantification of transcription factors during cellular differentiation using multiplexed targeted proteomics

Bart Deplancke, Felix Naef, Marc Moniatte, Adrian Schmid, Sunil Kumar Raghav, Irina Krier, Benjamin Zoller, Jovan Simicevic, Paola Alejandra Gilardoni

The cellular abundance of transcription factors (TFs) is an important determinant of their regulatory activities. Deriving TF copy numbers is therefore crucial to understanding how these proteins control gene expression. We describe a sensitive selected re ...

Nature Publishing Group2013

Adrian Schmid

Organohalide respiration: breakthrough towards the elucidation of the electron-accepting moiety of the respiratory chain

Absolute quantification of pceABCT gene products and characterization of the membrane protein complex responsible for the reduction of tetrachloroethene in Dehalobacter restrictus

ANAEROBIC BIODEGRADATION OF ORGANOHALIDE POLLUTANTS: A CRUCIAL STEP TOWARDS THE ELUCIDATION OF PROTEINS INVOLVED

Anaerobic Biodegradation of organohalide pollutants: a crucial step towards the elucidation of proteins involved

Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity

Flagellar membranes are rich in raft-forming phospholipids

Absolute quantification of transcription factors during cellular differentiation using multiplexed targeted proteomics

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Organohalide respiration: breakthrough towards the elucidation of the electron-accepting moiety of the respiratory chain

ANAEROBIC BIODEGRADATION OF ORGANOHALIDE POLLUTANTS: A CRUCIAL STEP TOWARDS THE ELUCIDATION OF PROTEINS INVOLVED

Flagellar membranes are rich in raft-forming phospholipids

Absolute quantification of pceABCT gene products and characterization of the membrane protein complex responsible for the reduction of tetrachloroethene in Dehalobacter restrictus

Anaerobic Biodegradation of organohalide pollutants: a crucial step towards the elucidation of proteins involved

Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity

Absolute quantification of transcription factors during cellular differentiation using multiplexed targeted proteomics