Publications de Corrado Cali | EPFL Graph Search

Digital Reconstruction of the Neuro-Glia-Vascular Architecture

Henry Markram, Kathryn Hess Bellwald, Lida Kanari, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Alexis Arnaudon, Corrado Cali, Michael Emiel Gevaert, Thomas Brice Delemontex

Astrocytes connect the vasculature to neurons mediating the supply of nutrients and biochemicals. They are involved in a growing number of physiological and pathophysiological processes that result from biophysical, physiological, and molecular interaction ...

OXFORD UNIV PRESS INC2021

Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments

Graham Knott, Corrado Cali, Nicole Déglon, Tamara Zehnder, Luca Pucci, Andrea Chicca

Astrocytes orchestrate neural development by powerfully coordinating synapse formation and function and, as such, may be critically involved in the pathogenesis of neurodevelopmental abnormalities and cognitive deficits commonly observed in psychiatric dis ...

2020

Norepinephrine stimulates glycogenolysis in astrocytes to fuel neurons with lactate

Pierre Magistretti, Henry Markram, Felix Schürmann, Daniel Keller, Corrado Cali, Jay Coggan

Although efficient compared to computers, the human brain utilizes energy at 10-fold the rate of other organs by mass. How the brain is supplied with sufficient on-demand energy to support its activity in the absence of neuronal storage capacity remains un ...

2018

A Process for Digitizing and Simulating Biologically Realistic Oligocellular Networks Demonstrated for the Neuro-Glio-Vascular Ensemble

Pierre Magistretti, Henry Markram, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Renaud Jolivet, Corrado Cali, Stefan Eilemann, Jay Coggan, Daniya Boges

One will not understand the brain without an integrated exploration of structure and function, these attributes being two sides of the same coin: together they form the currency of biological computation. Accordingly, biologically realistic models require ...

2018

Homeostatic control of dopamine by astrocytes in the postnatal maturation of the prefrontal cortex

Graham Knott, Corrado Cali, Tamara Zehnder, Luca Pucci

Wiley2017

Three-dimensional immersive virtual reality for studying cellular compartments in 3D models from EM preparations of neural tissues

Pierre Magistretti, Corrado Cali, Daniya Boges, Madhusudhanan Srinivasan

Advances in the application of electron microscopy (EM) to serial imaging are opening doors to new ways of analyzing cellular structure. New and improved algorithms and workflows for manual and semiautomated segmentation allow us to observe the spatial arr ...

Wiley-Blackwell2016

Grand Challenges for Global Brain Sciences

Sean Lewis Hill, Miguel Nicolelis, Corrado Cali

The next grand challenges for society and science are in the brain sciences. A collection of 60+ scientists from around the world, together with 10+ observers from national, private, and foundations, spent two days together discussing the top challenges th ...

2016

NeuroMorph: A Toolset for the Morphometric Analysis and Visualization of 3D Models Derived from Electron Microscopy Image Stacks

Pascal Fua, Graham Knott, Corrado Cali, Biagio Nigro, Anne Alison Jorstad, Marta Wawrzyniak

Serial electron microscopy imaging is crucial for exploring the structure of cells and tissues. The development of block face scanning electron microscopy methods and their ability to capture large image stacks, some with near isotropic voxels, is proving ...

Humana Press2015

Inferring connection proximity in networks of electrically coupled cells by subthreshold frequency response analysis

Henry Markram, Thomas Berger, Michele Giugliano, Corrado Cali, Michele Pignatelli

Electrical synapses continuously transfer signals bi-directionally from one cell to another, directly or indirectly via intermediate cells. Electrical synapses are common in many brain structures such as the inferior olive, the subcoeruleus nucleus and the ...

Springer US2008