Jörg Hülsken

Publications associées (44)

À propos
Confidentialité
Mentions légales

Graph Chatbot

β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells

Jörg Hülsken, Paloma Ordonez Moran

BACKGROUND: Cyclooxygenase-2 (COX-2) overexpression in colorectal cancer increases levels of its pro-tumorigenic product prostaglandin E2 (PGE(2)). The recently identified colorectal tumour suppressor 15-prostaglandin dehydrogenase (15-PGDH) catalyses pros ...

BMJ Publishing Group2011

Targeting extracellular matrix molecules for the treatment of cancer

Jörg Hülsken, Ilaria Malanchi

The present invention relates to an agent able to block a cancer supportive function of a fasciclin protein family member and to pharmaceutical compositions containing the same. ...

2011

SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas

Jörg Hülsken

Squamous cell carcinoma (SCC) of the lung is a frequent and aggressive cancer type. Gene amplifications, a known activating mechanism of oncogenes, target the 3q26-qter region as one of the most frequently gained/amplified genomic sites in SCC of various t ...

Public Library of Science2010

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo

Jörg Hülsken

Contributions of null and hypomorphic alleles of Apc in mice produce both developmental and pathophysiological phenotypes. To ascribe the resulting genotype-to-phenotype relationship unambiguously to the Wnt/beta-catenin pathway, we challenged the allele c ...

Public Library of Science2010

Canonical Wnt signalling plays essential roles

Jörg Hülsken

Wiley2009

Inducibility of Drug-metabolizing Enzymes by Xenobiotics in Mice with Liver-specific Knockout of Ctnnb1

Jörg Hülsken, Massimiliano Schwarz

Basal as well as xenobiotic-induced expression of the main enzymes from phase I and phase II of drug metabolism is confined to the perivenous areas of the mammalian liver lobule. Whereas signal transduction pathways that govern xenobiotic-induced expressio ...

2009

Tissue-specific stem cells: friend or foe?

Jörg Hülsken

2009

Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta- catenin signaling pathways in hair follicle induction

Jörg Hülsken, Yi Zhang

Wnt/beta-catenin and NF-kappaB signaling mechanisms provide central controls in development and disease, but how these pathways intersect is unclear. Using hair follicle induction as a model system, we show that patterning of dermal Wnt/beta-catenin signal ...

Cell Press - Elsevier2009

Cancer stem cells: never Wnt away from the niche

Jörg Hülsken, Ilaria Malanchi

PURPOSE OF REVIEW: The last years of cancer research have established the concept of cancer stem cells (CSCs) as a subpopulation of cells within a tumor entirely responsible for tumorigenesis. This has aroused expectations that targeting cancer stem cells ...

2009

T-cell development occurs in the combined absence of the canonical Wnt signal-transducers beta- and gamma-catenin

Jörg Hülsken, Fabien Kuttler, Ilaria Malanchi, Stéphane Duboux

2008

Page 4 sur 5

β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells

Jörg Hülsken, Paloma Ordonez Moran

BMJ Publishing Group2011

Targeting extracellular matrix molecules for the treatment of cancer

Jörg Hülsken, Ilaria Malanchi

The present invention relates to an agent able to block a cancer supportive function of a fasciclin protein family member and to pharmaceutical compositions containing the same. ...

2011