Jörg Hülsken

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Publications associées (44)

Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/beta-Catenin Transcriptional Activity

Jörg Hülsken, Paloma Ordonez Moran

Polycomb repressive complexes (PRCs) are among the most important gatekeepers of establishing and maintaining cell identity in metazoans. PRC1, which plays a dominant role in this context, executes its functions via multiple subcomplexes, which all contrib ...

Cell Press2016

Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis

Jörg Hülsken, Albert Santamaria Martinez

Integrins play an important role in haematopoietic stem cell (HSC) maintenance in the bone marrow niche. Here, we demonstrate that Periostin (Postn) via interaction with Integrin-alpha v (Itgav) regulates HSC proliferation. Systemic deletion of Postn resul ...

Nature Publishing Group2016

Successful Immunotherapy of Cancer Stem Cells Requires Memory and the Adaptive Immune System of the Host

Jörg Hülsken, Pierre Vincent Dessen, Patrick Schmidt, Nancy Thompson, Nicolas Pierre Desbaillets

Nature Publishing Group2015

HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer

Jörg Hülsken, Paloma Ordonez Moran, Caroline Dafflon

Hierarchical organization of tissues relies on stem cells, which either self-renew or produce committed progenitors predestined for lineage differentiation. Here we identify HOXA5 as an important repressor of intestinal stem cell fate in vivo and identify ...

Elsevier2015

SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer

Jörg Hülsken, Paloma Ordonez Moran, Anja Irmisch

SPROUTY2 (SPRY2) is an intracellular regulator of receptor tyrosine kinase signaling involved in cell growth, differentiation and tumorigenesis. Here, we show that SPRY2 is a target gene of the Wnt/beta-catenin pathway that is abnormally activated in more ...

Nature Publishing Group2014

Periostin Regulates Murine Adult Hematopoiesis By Affecting Hematopoietic Stem Cells Directly As Well Through Bone Formation

Jörg Hülsken, Albert Santamaria Martinez

Elsevier Science Inc2014

Putting cancer stem cells in context

Jörg Hülsken, Ilaria Malanchi

Elsevier Sci Ltd2013

Interactions Between Breast Cancer Stem Cells and their Niche Govern Metastatic Colonization of the Lung

Jörg Hülsken, Ilaria Malanchi

Elsevier Sci Ltd2012

Interactions between cancer stem cells and their niche govern metastatic colonization

Jörg Hülsken, Albert Santamaria Martinez, Ilaria Malanchi, Hans-Anton Lehr

Metastatic growth in distant organs is the major cause of cancer mortality. The development of metastasis is a multistage process with several rate-limiting steps. Although dissemination of tumour cells seems to be an early and frequent event, the successf ...

2012

Neural stem cells are increased after loss of β-catenin, but neural progenitors undergo cell death

Jörg Hülsken

Neurons and glia in the central nervous system originate from neural stem and progenitor cells that reside in the ventricular zones. Here we examine the role of beta-catenin in neural stem cell (NSC) regulation in mouse embryos lacking beta-catenin specifi ...

Wiley-Blackwell2011

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Periostin Regulates Murine Adult Hematopoiesis By Affecting Hematopoietic Stem Cells Directly As Well Through Bone Formation

Jörg Hülsken, Albert Santamaria Martinez

Elsevier Science Inc2014

Interactions between cancer stem cells and their niche govern metastatic colonization

Jörg Hülsken, Albert Santamaria Martinez, Ilaria Malanchi, Hans-Anton Lehr

2012