Publications de Katarzyna Pierzchala

Fast 3D 31P B1+ mapping with a weighted stack of spiral trajectory at 7 T

Lijing Xin, Katarzyna Pierzchala, Daniel Wenz, Mark Stephan Widmaier

Purpose: Phosphorus MRS (31P MRS) enables noninvasive assessment of energy metabolism, yet its application is hindered by sensitivity limitations. To overcome this, often high magnetic fields are used, leading to challenges such as spatial (Formula present ...

Wiley2025

Diffusion of brain metabolites highlights altered brain microstructure in type C hepatic encephalopathy: a 9.4 T preliminary study

Cristina Ramona Cudalbu, Katarzyna Pierzchala, Jessie Julie Mosso, Dunja Simicic

Introduction Type C hepatic encephalopathy (HE) is a decompensating event of chronic liver disease leading to severe motor and cognitive impairment. The progression of type C HE is associated with changes in brain metabolite concentrations measured by 1H m ...

Frontiers Media Sa2024

Inhibition of urease-mediated ammonia production by 2-octynohydroxamic acid in hepatic encephalopathy

Cristina Ramona Cudalbu, Katarzyna Pierzchala, Dunja Simicic, Stefanita-Octavian Mitrea

Hepatic encephalopathy is a neuropsychiatric complication of liver disease which is partly associated with elevated ammonemia. Urea hydrolysis by urease-producing bacteria in the colon is often mentioned as one of the main routes of ammonia production in t ...

Nature Portfolio2024

Effects of cholestasis and hyperammonemia on dendritic spine density and turnover in rat hippocampal neurons

Katarzyna Pierzchala

Adults and children with cholestatic liver disease are at risk for type C hepatic encephalopathy (HE) and may present lifelong neurocognitive impairment. While the underlying cellular and molecular mechanisms are still incompletely understood, ammonium and ...

Nature Portfolio2024

Brain Regional Differences in the Developing Brain Using an Animal Model of Type C Hepatic Encephalopathy

Cristina Ramona Cudalbu, Katarzyna Pierzchala, Dunja Simicic, Stefanita-Octavian Mitrea

Lippincott Williams & Wilkins2023

The Beneficial Effect of Oral Cr Supplementation in an Early Childhood Rat Model of Chronic Hepatic Encephalopathy: In Vivo Longitudinal 1H and 31P Magnetic Resonance Spectroscopy Study

Cristina Ramona Cudalbu, Katarzyna Pierzchala, Dunja Simicic, Stefanita-Octavian Mitrea

Lippincott Williams & Wilkins2023

Central Nervous System Oxidative Stress interplay with inflammation in a rat model of Type C Hepatic Encephalopathy - brothers in arms?

Cristina Ramona Cudalbu, Andrzej Sienkiewicz, Katarzyna Pierzchala, Dunja Simicic, Stefanita-Octavian Mitrea

ELSEVIER SCIENCE INC2023

Evaluation of a Hydroxamate-Based Urease Inhibitor in a Rodent Model of Hepatic Encephalopathy

Cristina Ramona Cudalbu, Katarzyna Pierzchala, Dunja Simicic, Stefanita-Octavian Mitrea

Lippincott Williams & Wilkins2023

Lessons on brain edema in HE: from cellular to animal models and clinical studies

Cristina Ramona Cudalbu, Katarzyna Pierzchala, Jessie Julie Mosso

Brain edema is considered as a common feature associated with hepatic encephalopathy (HE). However, its central role as cause or consequence of HE and its implication in the development of the neurological alterations linked to HE are still under debate. I ...

SPRINGER/PLENUM PUBLISHERS2023

SPARCQ: A new approach for fat fraction mapping using asymmetries in the phase-cycled balanced SSFP signal profile

Tobias Kober, Tom Hilbert, Katarzyna Pierzchala

Purpose: To develop SPARCQ (Signal Profile Asymmetries for Rapid Compartment Quantification), a novel approach to quantify fat fraction (FF) using asymmetries in the phase-cycled balanced SSFP (bSSFP) profile. ...

WILEY2023