Publications de Davide Demurtas

Novel features of centriole polarity and cartwheel stacking revealed by cryo-tomography

Davide Demurtas, Georgios Hatzopoulos, Sergey Nazarov, Alexandra Bezler, Paul Guichard, Veronika Nemcíková Villímová

Centrioles are polarized microtubule-based organelles that seed the formation of cilia, and which assemble from a cartwheel containing stacked ring oligomers ofSAS-6 proteins. A cryo-tomography map of centrioles from the termite flagellateTrichonymphaspp. ...

2020

Rationally designed Human Cytomegalovirus gB nanoparticle vaccine with improved immunogenicity

Davide Demurtas

Author summary Human cytomegalovirus (HCMV) infection is the foremost viral cause of congenital birth defects. Attempts to vaccinate against HCMV brought moderate, though not sufficient, reduction in infection. Moreover, phase II clinical trial with gB for ...

PUBLIC LIBRARY SCIENCE2020

Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients

Davide Demurtas, Romain Hamelin, Melody Swartz, Lambert Charles François Potin, Patricia Corthésy Henrioud, Natacha Anne-Sophie Bordry, Maria Anna Sofia Broggi, Léa Maillat, Alexandre Harari

Liquid biopsies allow monitoring of cancer progression and detection of relapse, but reliable biomarkers in melanoma are lacking. Because secreted factors preferentially drain to lymphatic vessels before dilution in the blood, we hypothesized that lymph sh ...

ROCKEFELLER UNIV PRESS2019

KAP1 is an antiparallel dimer with a functional asymmetry

Didier Trono, Matteo Dal Peraro, Beat Fierz, Davide Demurtas, Maria Josefina Marcaida Lopez, Louise Catherine Bryan, Giulia Fonti, Pierre-Yves Joseph Laurent Helleboid, Alexandra Styliani Kalantzi

KAP1 (KRAB domain-associated protein 1) plays a fundamental role in regulating gene expression in mammalian cells by recruiting different transcription factors and altering the chromatin state. In doing so, KAP1 acts both as a platform for macromolecular i ...

Life Science Alliance, LLC2019

Flagellar microtubule doublet assembly in vitro reveals a regulatory role of tubulin C-terminal tails

Davide Demurtas, Paul Guichard, Virginie Hamel

Microtubule doublets (MTDs), consisting of an incomplete B-microtubule at the surface of a complete A-microtubule, provide a structural scaffold mediating intraflagellar transport and ciliary beating. Despite the fundamental role of MTDs, the molecular mec ...

AMER ASSOC ADVANCEMENT SCIENCE2019

Primary human and rat beta cells release the intracellular autoantigens GAD65, IA-2 and proinsulin in exosomes together with cytokine-induced enhancers of immunity

Michele De Palma, Davide Demurtas, Romain Hamelin, Jeffrey Alan Hubbell, Melody Swartz, Steinunn Baekkeskov Hanahan, Sachiko Hirosue, Chiara Cianciaruso, Miriella Carmela Pasquier, Edward Allen Phelps

The target autoantigens in several organ-specific autoimmune diseases, including type 1 diabetes (T1D), are intracellular membrane proteins, whose initial encounter with the immune system is poorly understood. Here we propose a new model for how these prot ...

American Diabetes Association2017

A Cationic Micelle Complex Improves CD8+T Cell Responses in Vaccination Against Unmodified Protein Antigen

Davide Demurtas, Jeffrey Alan Hubbell, Melody Swartz, Carrie Ellen Brubaker, Daniel Kenneth Bonner, Vasiliki Panagiotou

Nanoscale carrier platforms promote immune responses to vaccination by facilitating delivery of vaccine components to immunologically relevant sites. The technique is particularly valuable for subunit vaccination, in which coadministration of immunostimula ...

Amer Chemical Soc2016

Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint

Davide Demurtas, Marc Moniatte, Adrian Schmid, Cyntia De Piano, Nikita Rudinskiy, Christophe Fuerer

Amyloid-beta (A beta) peptide oligomerization plays a central role in the pathogenesis of Alzheimer's disease (AD), and A beta oligomers are collectively considered an appealing therapeutic target for the treatment of AD. However, the molecular mechanisms ...

Elsevier Science Inc2016

Molecular screening of cancer-derived exosomes by surface plasmon resonance spectroscopy

Horst Vogel, Niels Erik Lion, Davide Demurtas, Luigino Grasso, Michel Prudent, Romain Wyss, Ashwin Thampi, Lorenz Weidenauer

We report on a generic method to detect and iden- tify the molecular profile of exosomes either derived from cultured cell lines or isolated from biofluids. Exosomes are nanovesicles shed by cells into their microenvironment and carry the molecular identit ...

Springer Heidelberg2015

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Davide Demurtas

Novel features of centriole polarity and cartwheel stacking revealed by cryo-tomography

Rationally designed Human Cytomegalovirus gB nanoparticle vaccine with improved immunogenicity

Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients

KAP1 is an antiparallel dimer with a functional asymmetry

Flagellar microtubule doublet assembly in vitro reveals a regulatory role of tubulin C-terminal tails

Primary human and rat beta cells release the intracellular autoantigens GAD65, IA-2 and proinsulin in exosomes together with cytokine-induced enhancers of immunity

A Cationic Micelle Complex Improves CD8+T Cell Responses in Vaccination Against Unmodified Protein Antigen

Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint

Santosomes as natural and efficient carriers for the improvement of phycocyanin reepithelising ability in vitro and in vivo

Molecular screening of cancer-derived exosomes by surface plasmon resonance spectroscopy

Graph Chatbot

Chattez avec Graph Search

Novel features of centriole polarity and cartwheel stacking revealed by cryo-tomography

Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint

Primary human and rat beta cells release the intracellular autoantigens GAD65, IA-2 and proinsulin in exosomes together with cytokine-induced enhancers of immunity

A Cationic Micelle Complex Improves CD8+T Cell Responses in Vaccination Against Unmodified Protein Antigen

Flagellar microtubule doublet assembly in vitro reveals a regulatory role of tubulin C-terminal tails

Molecular screening of cancer-derived exosomes by surface plasmon resonance spectroscopy

Santosomes as natural and efficient carriers for the improvement of phycocyanin reepithelising ability in vitro and in vivo

Rationally designed Human Cytomegalovirus gB nanoparticle vaccine with improved immunogenicity

KAP1 is an antiparallel dimer with a functional asymmetry

Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients