The receptor-like protein kinase PknB from Mycobacterium tuberculosis is encoded by the distal gene in a highly conserved operon, present in all actinobacteria, that may control cell shape and cell division. Genes coding for a PknB-like protein kinase are ...

2006

The twin arginine translocation (Tat) system is used by many bacteria to export fully folded proteins containing cofactors. Here, we show genetically that this system is essential for Mycobacterium tuberculosis, as the tatAC operon and tatB genes could be ...

2006

The crystal structure of Rv0813c from Mycobacterium tuberculosis reveals a new family of fatty acid-binding protein-like proteins in bacteria

Stewart Cole

The gene Rv0813c from Mycobacterium tuberculosis, which codes for a hypothetical protein of unknown function, is conserved within the order Actinomycetales but absent elsewhere. The crystal structure of Rv0813c reveals a new family of proteins that resembl ...

2006

Towards an immunodiagnostic test for leprosy

Stewart Cole

In addition to multidrug therapy, elimination of leprosy requires improved diagnostic methods. Using a comparative genomics approach, 17 potential protein antigens (MLP) that are restricted to Mycobacterium leprae, or of limited distribution, were produced ...

2006

Bordetella pertussis adenylate cyclase (CyaA) toxoid is a powerful nonreplicative immunization vector targeting dendritic cells, which has already been used successfully in prophylactic and therapeutic vaccination in various preclinical animal models. Here ...

2006

Search for lepton and baryon number violating τ- decays into Λ̄π- and Λπ-

Olivier Schneider, Stewart Cole, Chao Wang, Tagir Aushev, Lei Zhang, Vladislav Balagura, Sun Hee Kim, Ji Hyun Kim

We have searched for τ lepton decays, τ-→Λ̄π- and τ-→Λπ-, that simultaneously violate the conservation of the lepton (L) and baryon (B) number using a data sample of 154 fb-1 collected with the Belle detector at the KEKB e+e- asymmetric-energy collider. No ...

2006

Search for neutrinoless decays τ → ℓ h h and τ → ℓ V0

Olivier Schneider, Aurelio Bay, Stewart Cole, Sun Hee Kim

We have searched for neutrinoless τ lepton decays into ℓhh or ℓ V0, where ℓ stands for an electron or muon, h for a charged light hadron, π or K, and V0 for a neutral vector meson, ρ0, K* (892)0 and φ{symbol}, using a 158 fb-1 data sample collected with th ...

2006