Publications de Daniel Ortiz Trujillo

Polycondensation as a Universal Method for Preparing High-density Single-atom Catalyst Libraries

Paul Joseph Dyson, Mounir Driss Mensi, Pascal Miéville, Laura Piveteau, Xunhui Wang, Xinbang Wu, Daniel Ortiz Trujillo, Miyeon Chang, Ariana Serban, Timo Markus Oskar Felder

Single-atom catalysts (SACs) present a promising subclass of classic heterogeneous catalysts by maximizing metal dispersion and enhancing efficiency. Although high-density SACs (HD-SACs) are reported, their synthesis is typically constrained to specific me ...

WILEY-V C H VERLAG GMBH2025

New melphalan derivatives for the treatment of retinoblastoma in combination with thermotherapy

Paul Joseph Dyson, Farzaneh Fadaei Tirani, Aurélien Bornet, Daniel Ortiz Trujillo

Of the different modalities used to treat retinoblastoma, a chemothermotherapeutic regimen combining carboplatin and thermotherapy (also termed focal therapy), and the application of melphalan as a monotherapy, are particularly successful. Some studies ind ...

Royal Soc Chemistry2024

Radiation Chemistry Reveals the Reaction Mechanisms Involved in the Reduction of Vinylene Carbonate in the Solid Electrolyte Interphase of Lithium-Ion Batteries

Laura Piveteau, Daniel Ortiz Trujillo

A safe and efficient lithium-ion battery requires including an additive in the electrolyte. Among the additives used, vinylene carbonate (VC) is particularly interesting, because it leads to the formation of a stable and protective solid electrolyte interp ...

2024

A redox-responsive prodrug for tumor-targeted glutamine restriction

Xile Hu, Li Tang, Daniel Ortiz Trujillo, Bing Feng, Céline Jasmin Prange

Modulating the metabolism of cancer cells, immune cells, or both is a promising strategy to potentiate cancer immunotherapy in the nutrient-competitive tumor microenvironment. Glutamine has emerged as an ideal target as cancer cells highly rely on glutamin ...

Elsevier2024

Competitive binding studies of the nucleosomal histone targeting drug, [Ru (eta(6)-p-cymene)Cl-2(pta)] (RAPTA-C), with oligonucleotide-peptide mixtures

Paul Joseph Dyson, Daniel Ortiz Trujillo

Protein crystallography and biochemical assays reveal that the organometallic drug, [Ru(eta(6)-p-cymene)Cl-2(pta)] (RAPTA-C), preferentially binds to nucleosomal histone proteins in chromatin. To better understand the binding mechanism we report here a mas ...

ELSEVIER SCIENCE INC2023

Development of an inhalable antiviral powder formulation against respiratory syncytial virus

Francesco Stellacci, Daniel Ortiz Trujillo, Paulo Henrique Jacob Silva, Matteo Gasbarri

Respiratory viruses including the respiratory syncytial virus (RSV) aggravate the global burden of virus-inflicted morbidity and mortality. Entry inhibitors are a promising class of antiviral drugs for combating these viruses, as they can prevent infection ...

ELSEVIER2023

Autocatalytic O-Formylation of Alcohols Using CO2

Paul Joseph Dyson, Daniel Ortiz Trujillo

Global drive away from fossil feedstock requires the development of synthetic procedures to enhance the efficiency of CO2 capture and utilization processes using renewable starting materials and catalysts. Here, we report an alternative reaction pathway fo ...

AMER CHEMICAL SOC2023

Ruthenium(II)-Arene Complexes with Glycosylated NHC-Carbene Co-Ligands: Synthesis, Hydrolytic Behavior, and Binding to Biological Molecules

Paul Joseph Dyson, Rosario Scopelliti, Farzaneh Fadaei Tirani, Daniel Ortiz Trujillo, Mouna Hadiji

Ruthenium(II) complexes with a three-legged piano-stool structure based on an arene ring, an N-heterocyclic carbene (NHC)-carbene ligand with a peracetylated glucose moiety and two chlorides or one bidentate ligand, were prepared and characterized by spect ...

AMER CHEMICAL SOC2023

Hyperpolarized (1-13C)Alaninamide Is a Multifunctional In Vivo Sensor of Aminopeptidase N Activity, pH, and CO2

Rolf Gruetter, Daniel Ortiz Trujillo, Hikari Ananda Infinity Yoshihara, Alice Radaelli

Spin hyperpolarization enables real-time metabolic imaging of carbon-13-labeled substrates. While hyperpolarized L- (1-13C)alaninamide is a probe of the cell-surface tumor marker aminopeptidase-N (APN, CD13), its activity in vivo has not been described. Sc ...

AMER CHEMICAL SOC2022

Simultaneous mass spectrometry analysis of cisplatin with oligonucleotide-peptide mixtures: implications for the mechanism of action

Paul Joseph Dyson, Laure Menin, Luc Patiny, Daniel Ortiz Trujillo

Although genomic DNA is the primary target of anticancer platinum-based drugs, interactions with proteins also play a significant role in their overall activity. In this study, competitive binding of cisplatin with an oligonucleotide and two peptides corre ...

SPRINGER2022