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Pyruvate membrane crossing and its lactate dehydrogenase-mediated conversion to lactate in cells featuring different levels of expression of membrane monocarboxylate transporters (MCT4) were probed by dissolution dynamic nuclear polarization-enhanced NMR. ...
The main limitation of NMR-based investigations is low sensitivity. This prompts for long acquisition times, thus preventing real-time NMR measurements of metabolic transformations. Hyperpolarization via dissolution DNP circumvents part of the sensitivity ...
We present a high precision particle-by-particle 3D reconstruction of granular systems composed of monodispersed spheres (sphere packings); the experimental approach is based on magnetic resonance imaging techniques. Our measurements revealed a strong corr ...
Springer Berlin Heidelberg2013
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Hyperpolarization by dissolution dynamic nuclear polarization (DNP) is a versatile technique to dramatically enhance the nuclear magnetic resonance (NMR) signal intensity of insensitive long-T1 nuclear spins such as 6 Li. The 6 Li longitudinal relaxation o ...
Wiley-Blackwell2016
Since the introduction 10 years ago of the dissolution method, Dynamic Nuclear Polarization (DNP) became a widely applied and powerful technique to enhance nuclear magnetic resonance (NMR) signals of low naturally abundant, insensitive nuclear spins for an ...
EPFL2013
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The most versatile method to increase liquid-state 13C NMR sensitivity is dissolution dynamic nuclear polarization. The use of trityl radicals is usually required to obtain very large 13C polarization via this technique. We herein demonstrate that up to 35 ...
Royal Soc Chemistry2013
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Packings of granular materials are complex systems consisting of large sets of particles interacting via contact forces. Their internal structure is interesting for several theoretical and practical reasons, especially when the model system consists in a l ...