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Gregor Kiefer

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Publications associées (11)

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Vinyl triazenes were obtained by enantioselective [2+2] cycloaddition reactions of bicyclic alkenes with 1-alkynyl triazenes in the presence of a RuII catalyst with a chiral cyclopentadienyl ligand. These triazenes serve as unique vinyl cation surrogates. ...

2017

Novel Applications of Nitrous Oxide and Transition Metals for C-C and C-N Bond Formation

Gregor Kiefer

This thesis describes novel methods for and investigations into C–C and C–N bond formation reactions. Chapter 1 gives a very brief overview of established strategies for the formation of new C–C bonds in organic synthesis. In chapter 2, a multi‐step one‐po ...

EPFL2015

1-Alkynyltriazenes as Functional Analogues of Ynamides

Rosario Scopelliti, Kay Severin, Jérôme Waser, Gregor Kiefer, Sophie Lucie Racine, Loïc Nicolas Jeanbourquin, Florian Gérald Abela, Daniele Perrotta

The chemical reactivity of 1-alkynyltriazenes has been investigated and is found to parallel the reactivity of ynamides. The similarity in reactivity of these two classes of compounds is demonstrated by addition reactions with acids, by cycloaddition react ...

Wiley-Blackwell2015

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Triazenes are valuable compounds in organic chemistry and numerous applications have been reported. Furthermore, triazenes have been investigated extensively as potential antitumor drugs. Here, we describe a new method for the synthesis of triazenes. The p ...

Wiley-Blackwell2015

The present invention relates to a novel method for preparing triazenes. Further, the invention relates to novel triazenes and the use of N2O for preparing a compound comprising a triazene group. Further, the invention relates to the use of the novel triaz ...

2015

Oxidative Coupling Reactions of Grignard Reagents with Nitrous Oxide

Kay Severin, Gregor Kiefer, Loïc Nicolas Jeanbourquin

Catalysis with laughing gas: N2O in combination with transition-metal catalysts allow the oxidative homo- and cross-coupling of Grignard reagents. The reactions can be performed under mild conditions despite the inert character of N2O. ...

Wiley-Blackwell2013

The Intricate Chemistry of Cobalt(II) Halides and Bis(diphenylphosphanyl)ethane

Rosario Scopelliti, Kay Severin, Heron Vrubel, Gregor Kiefer

Phosphane complexes of the putative formula [CoX2(dppe)] [X = Cl, Br, I; dppe = bis(diphenylphosphanyl)ethane] are frequently used catalyst precursors in cobalt-catalyzed reactions. Despite their widespread use, these complexes have not been structurally c ...

Wiley-Blackwell2013

Ruthenium-Catalyzed Sequential Enyne Cross-Metathesis/ATRA Reactions

Kay Severin, Euro Solari, Gregor Kiefer, Jesus Ruiz

Sequential enyne cross-metathesis reactions of arylalkynes with ethylene followed by atom transfer radical addition (ATRA) with ethyl dichloroacetate or dichloroacetonitrile provide 1,5-dichloropent-2-ene derivatives. The second-generation Grubbs alkyliden ...

Wiley-Blackwell2012

RhCl3-Mediated Coupling Reactions of tert-Butyl Acetylene

Rosario Scopelliti, Kay Severin, Euro Solari, Gregor Kiefer, Barnali Dutta

RhCl3 is shown to mediate unusual coupling reactions of tert-butyl acetylene. When RhCl3(H2O)n was heated with four equivalents of tert-butyl acetylene in methanol, the dinuclear complex [{Rh(μ-Cl)(CH2tBu)(tBuC=CHCOCH2tBu)}2] (2) was isolated. A larger exc ...

Wiley-Blackwell2012

Ruthenium vs. Osmium Complexes as Catalysts for Atom Transfer Radical Addition Reactions

Rosario Scopelliti, Kay Severin, Gregor Kiefer, Katrin Anne Thommes

The catalytic activity of [Cp*OsBr2(PPh3)] in conjunction with Mg has been evaluated for atom transfer radical addition (ATRA) and cyclization (ATRC) reactions. The Os complex enabled these reactions to be performed with similar efficiency as that of the a ...

Wiley-Blackwell2010