Publications de Carlotta Guiducci

Electrokinetic microdevices for biological sample processing

Carlotta Guiducci, Pierre-Emmanuel Marie Thiriet, Gloria Porro

Microsystems combining fluid dynamics and electric-field-induced forces have emerged as powerful tools for manipulating and isolating biological species. Advances in electrokinetic theory, combined with optimized microfabrication processes, are at the core ...

Springer Science and Business Media LLC2024

MarrowCellDLD: a microfluidic method for label-free retrieval of fragile bone marrow-derived cells

Carlotta Guiducci, Gloria Porro

Functional bone marrow studies have focused primarily on hematopoietic progenitors, leaving limited knowledge about other fragile populations, such as bone marrow adipocytes (BMAds) and megakaryocytes. The isolation of these cells is challenging due to rup ...

Nature Portfolio2023

Prediction of Dispersion Rate of Airborne Nanoparticles in a Gas-Liquid Dual-Microchannel Separated by a Porous Membrane: A Numerical Study

Carlotta Guiducci, Zohreh Sheidaei

Recently, there has been increasing attention toward inhaled nanoparticles (NPs) to develop inhalation therapies for diseases associated with the pulmonary system and investigate the toxic effects of hazardous environmental particles on human lung health. ...

MDPI2022

Particle-sorting fluidic device and methods for using thereof

Carlotta Guiducci, Gloria Porro, Kevin Keim

Device, system and method for sorting particles comprised into a fluid are disclosed that improve the current settings of deterministic lateral displacement (DLD)-based microfluidic devices, so to sort and detect small particles such as extracellular vesic ...

2022

Device to carry out semiconductor-based diagnostics

Carlotta Guiducci, Saurabh Tomar

The present invention relates to a device to carry out semiconductor based molecular diagnostics comprising a microfluidic chip carrier 1, an elastomer microfluidic module 2 and a CMOS chip 3, one surface of said microfluidic module facing and contacting o ...

2022

Integration of Ultra-Low Volume Pneumatic Microfluidics with a Three-Dimensional Electrode Network for On-Chip Biochemical Sensing

Carlotta Guiducci, Saurabh Tomar, Thomas Ernst

This paper reports a novel miniaturized pseudo reference electrode (RE) design for biasing Ion Sensitive Field Effect Transistors (ISFETs). It eliminates the need for post-CMOS processing and can scale up in numbers with the CMOS scaling. The presented des ...

2021

Dielectrophoresis detection device

Carlotta Guiducci, Pierre-Emmanuel Marie Thiriet

A dielectrophoretic detection device comprising a chip, with a flow channel having at least one inlet and one outlet, and at least a detection area configured to detect analytes trapped on functionalised beads flowing within said flow channel, a first and ...

2021

Device and method for pre-term birth risk assessment

Carlotta Guiducci, Erick Antonio Garcia Cordero, David Baud, Gloria Porro

The invention relates to a vaginal fluid monitoring device embedded into a feminine sanitary pad, said device comprising a stack of the following elements: An absorbent layer (100) configured to be in proximity to, and collect, a vaginal fluid; and A biose ...

2021

Selective Retrieval of Individual Cells from Microfluidic Arrays Combining Dielectrophoretic Force and Directed Hydrodynamic Flow

Bart Deplancke, Carlotta Guiducci, Jörn Pezoldt, Pierre-Emmanuel Marie Thiriet, Gabriele Gambardella, Kevin Keim

Hydrodynamic-based microfluidic platforms enable single-cell arraying and analysis over time. Despite the advantages of established microfluidic systems, long-term analysis and proliferation of cells selected in such devices require off-chip recovery of ce ...

MDPI2020

Rapid Multianalyte Microfluidic Homogeneous Immunoassay on Electrokinetically Driven Beads

Carlotta Guiducci, Pierre-Emmanuel Marie Thiriet, Gloria Porro, Danashi Imani Medagoda

The simplicity of homogeneous immunoassays makes them suitable for diagnostics of acute conditions. Indeed, the absence of washing steps reduces the binding reaction duration and favors a rapid and compact device, a critical asset for patients experiencing ...

2020