Publications de Romain Hamelin

Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation

Graham Knott, Romain Hamelin, Anne-Laure Mahul Mellier, Nadine Aït Bouziad, Jonathan Jean-Pierre Ricci, Yllza Jasiqi, Mary-Claude Croisier-Coeytaux, Anass Chiki, Melek Firat Altay, Somanath Jagannath

Alpha-synuclein (aSyn) post-translational modifications (PTM), especially phosphorylation at serine 129 and C-terminal truncations, are highly enriched in Lewy bodies (LB), Lewy neurites, and other pathological aggregates in Parkinson's disease and synucle ...

Springer Science and Business Media LLC2025

Casein Kinases 2-dependent phosphorylation of the placental ligand VAR2CSA regulates Plasmodium falciparum-infected erythrocytes cytoadhesion

Romain Hamelin

Placental malaria is characterized by the massive accumulation and sequestration of infected erythrocytes in the placental intervillous blood spaces, causing severe birth outcomes. The variant surface antigen VAR2CSA is associated with Plasmodium falciparu ...

2025

Conditional essentiality of the 11-subunit complex I-like enzyme in strict anaerobes: the case of Desulfitobacterium hafniense strain DCB-2

Christof Holliger, Julien Maillard, Romain Hamelin, Mathilde Stéphanie Willemin, Florence Armand

In oxidative phosphorylation, respiratory complex I serves as an entry point in the electron transport chain for electrons generated in catabolic processes in the form of NADH. An ancestral version of the complex, lacking the NADH-oxidising module, is enco ...

Frontiers Media SA2024

Organ-specific electrophile responsivity mapping in live C. elegans

Romain Hamelin, Balázs Álmos Novotny, Daniel Ahmet Urul, Amogh Kulkarni

Proximity labeling technologies are limited to indexing localized protein residents. Such data—although valuable—cannot inform on small-molecule responsivity of local residents. We here bridge this gap by demonstrating in live C. elegans how electrophile-s ...

2024

Phosphoproteomics and morphology of stored human red blood cells treated by protein tyrosine phosphatases inhibitor

Gerardo Turcatti, Benjamin Rappaz, Romain Hamelin, Florence Armand

The process of protein phosphorylation is involved in numerous cell functions. In particular, phosphotyrosine (pY) has been reported to play a role in red blood cell (RBC) functions, including the cytoskeleton organization. During their storage before tran ...

2023

Resistance mechanism to Notch inhibition and combination therapy in human T-cell acute lymphoblastic leukemia

Freddy Radtke, Romain Hamelin, Nadine Fournier, Florence Armand, Maria Pavlou, Linlin Cao

Gain-of-function mutations in NOTCH1 are among the most frequent genetic alterations in T-cell acute lymphoblastic leukemia (T-ALL), highlighting the Notch signaling pathway as a promising therapeutic target for personalized medicine. Yet, a major limitati ...

2023

Proteome adaptations of the organohalide-respiring Desulfitobacterium hafniense strain DCB-2 to various energy metabolisms

Christof Holliger, Julien Maillard, Romain Hamelin, Mathilde Stéphanie Willemin, Florence Armand

IntroductionDesulfitobacterium hafniense was isolated for its ability to use organohalogens as terminal electron acceptors via organohalide respiration (OHR). In contrast to obligate OHR bacteria, Desulfitobacterium spp. show a highly versatile energy meta ...

Frontiers Media SA2023

Regulation of Src tumor activity by its N-terminal intrinsically disordered region

Romain Hamelin, Florence Armand

The membrane-anchored Src tyrosine kinase is involved in numerous pathways and its deregulation is involved in human cancer. Our knowledge on Src regulation relies on crystallography, which revealed intramolecular interactions to control active Src conform ...

SPRINGERNATURE2022

Function-guided proximity mapping unveils electrophilic-metabolite sensing by proteins not present in their canonical locales

Yimon Aye, Romain Hamelin, Pierre Alexander Miranda Herrera, Yi Zhao

Enzyme-assisted posttranslational modifications (PTMs) constitute a major means of signaling across different cellular compartments. However, how nonenzymatic PTMs-despite their direct relevance to covalent drug development-impinge on crosscompartment sign ...

National Academy of Sciences2022

Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization

Romain Hamelin, Florence Armand, Nicola Harris, Kathleen Shah, Mati André Marie Moyat

The intestine harbors a large population of resident eosinophils, yet the function of intestinal eosinophils has not been explored. Flow cytometry and whole-mount imaging identified eosinophils residing in the lamina propria along the length of the intesti ...

CELL PRESS2022