Francesco Stellacci

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Publications associées (214)

A pan-respiratory virus attachment inhibitor with high potency in human airway models and in vivo

Francesco Stellacci

Respiratory viruses can cause severe infections, often leading to hospitalization or death, and pose a major pandemic threat. No broad-spectrum antiviral is currently available. However, most respiratory viruses use sialic acid or heparan sulfates as attac ...

2025

Robot-Assisted Measurement of the Critical Micelle Concentration

Francesco Stellacci, Josephine Anna Eleanor Hughes

The critical micelle concentration (CMC) is the key characterization of surfactants. To date, no method can yield sequential CMC measurements in an automated fashion. This work introduces SIMO (smart integrator for manual operations), a novel robotic platf ...

WILEY2025

Long-Term Protein Synthesis with PURE in a Mesoscale Dialysis System

Francesco Stellacci, Sebastian Maerkl, Laura Sophie Grasemann

Cell-free systems are powerful tools in synthetic biology with versatile and wide-ranging applications. However, a significant bottleneck for these systems, particularly the PURE cell-free system, is their limited reaction lifespan and yield. Dialysis offe ...

2025

Structure-Activity Relationship Studies of Glycosaminoglycan Mimetic Macrocycles Against Herpes

Francesco Stellacci, Paulo Henrique Jacob Silva

The herpes simplex virus (HSV) is associated with serious conditions, such as encephalitis and blindness, and its infection is closely linked to significant vascular complications and coagulation issues, particularly in individuals with compromised immune ...

AMER CHEMICAL SOC2025

Structure-Property Relationships of Elastomeric Vinylogous Urethane Thermosets and Their Application as Closed-Loop Recyclable Strain Sensors

Francesco Stellacci, Youwei Ma

Developing closed-loop recyclable thermosets and understanding their structure-property relationships are essential steps in advancing a circular materials economy. Here, we present a vinylogous urethane (VU) thermoset with closed-loop recyclability, synth ...

American Chemical Society2025

Reaction of β-Ketoester and 1,3-Diol to Access Chemically Recyclable and Mechanically Robust Poly(vinyl alcohol) Thermosets through Incorporation of β-(1,3-dioxane)ester

Francesco Stellacci, Youwei Ma

The development of mechanically robust, chemically stable, and yet recyclable polymers represents an essential undertaking in the context of advancing a circular economy for plastics. Here, we introduce a novel cleavable β-(1,3-dioxane)ester (DXE) linkage, ...

Wiley-VCH Verlag GmbH2024

Benzene with Alkyl Chains Is a Universal Scaffold for Multivalent Virucidal Antivirals

Francesco Stellacci, Heyun Wang, Paulo Henrique Jacob Silva, Matteo Gasbarri, Lixia Wei, Yong Zhu

Most viruses start their invasion by binding to glycoproteins' moieties on the cell surface (heparan sulfate proteoglycans [HSPG] or sialic acid [SA]). Antivirals mimicking these moieties multivalently are known as broad-spectrum multivalent entry inhibito ...

Amer Chemical Soc2024

Supramolecular Architectures of Dendritic Polymers Provide Irreversible Inhibitor to Block Viral Infection

Francesco Stellacci, Heyun Wang, Matteo Gasbarri

In Nature, most known objects can perform their functions only when in supramolecular self-assembled from, e.g. protein complexes and cell membranes. Here, a dendritic polymer is presented that inhibits severe acute respiratory syndrome coronavirus 2 (SARS ...

Wiley2024

Versatile Capillary Cells for Handling Concentrated Samples in Analytical Ultracentrifugation

Francesco Stellacci, Quy Ong Khac, Xufeng Xu

In concentrated macromolecular dispersions, far-from-ideal intermolecular interactions determine the dispersion behaviors including phase transition, crystallization, and liquid-liquid phase separation. Here, we present a novel versatile capillary-cell des ...

Amer Chemical Soc2024

Nature-inspired recycling of a protein mixture into a green fluorescent protein-based hydrogel

Francesco Stellacci, Sebastian Maerkl

Protein-based materials are biocompatible and have a variety of remarkable properties; consequently, they are finding more and more applications. Nature recycles proteins in multiple ways, ranging from bio-degradation (a slow approach) to fast recycling of ...

2024

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Reaction of β-Ketoester and 1,3-Diol to Access Chemically Recyclable and Mechanically Robust Poly(vinyl alcohol) Thermosets through Incorporation of β-(1,3-dioxane)ester

Francesco Stellacci, Youwei Ma

Wiley-VCH Verlag GmbH2024

Long-Term Protein Synthesis with PURE in a Mesoscale Dialysis System

Francesco Stellacci, Sebastian Maerkl, Laura Sophie Grasemann

2025

Structure-Property Relationships of Elastomeric Vinylogous Urethane Thermosets and Their Application as Closed-Loop Recyclable Strain Sensors

Francesco Stellacci, Youwei Ma

American Chemical Society2025