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Francesco Stellacci

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Publications associées (214)

Modulating Weak Protein-Protein Cross-Interactions by the Addition of Free Amino Acids at Millimolar Concentrations

Francesco Stellacci, Cécilia Laetitia Carla Siri, Pamina Winkler

In this paper, we quantify weak protein-protein interactions in solution using cross-interaction chromatography (CIC) and surface plasmon resonance (SPR) and demonstrate that they can be modulated by the addition of millimolar concentrations of free amino ...

2024

Amino Acids and Their Biological Derivatives Modulate Protein-Protein Interactions in an Additive Way

Francesco Stellacci, Xufeng Xu

Protein-protein interactions (PPIs) differ when measured in test tubes and cells due to the complexity of the intracellular environment. Free amino acids (AAs) and their derivatives constitute a significant fraction of the intracellular volume and mass. Re ...

2024

Two-component paint, antimicrobial surface and preparation method thereof

Francesco Stellacci

Herein described is a two-component paint comprising a first component containing a first solvent and polymer particles comprising particle functional groups that are negatively or positively charged and a second component containing a second solvent and a ...

2024

Inhibition of influenza virus infection in mice by pulmonary administration of a spray dried antiviral drug

Francesco Stellacci, Aurélien Bornet, Paulo Henrique Jacob Silva

Increasing resistance to antiviral drugs approved for the treatment of influenza urges the development of novel compounds. Ideally, this should be complemented by a careful consideration of the administration route. 6′siallyllactosamine-functionalized β-cy ...

2024

Amino acids modulate liquid-liquid phase separation in vitro and in vivo by regulating protein-protein interactions

Francesco Stellacci, Xufeng Xu

Copyright © 2024 the Author(s). Published by PNAS.Liquid-liquid phase separation (LLPS) is an intracellular process widely used by cells for many key biological functions. It occurs in complex and crowded environments, where amino acids (AAs) are vital com ...

National Academy of Sciences2024

Combining external physical stimuli and nanostructured materials for upregulating pro-regenerative cellular pathways in peripheral nerve repair

Silvestro Micera, Francesco Stellacci

Peripheral nerve repair remains a major clinical challenge, particularly in the pursuit of therapeutic approaches that ensure adequate recovery of patient's activity of daily living. Autografts are the gold standard in clinical practice for restoring lost ...

FRONTIERS MEDIA SA2024

Development of Broad-Spectrum β-Cyclodextrins-Based Nanomaterials Against Influenza Viruses

Francesco Stellacci, Paulo Henrique Jacob Silva, Yong Zhu

In recent decades, epidemics and pandemics have multiplied throughout the world, with viruses generally being the primary responsible agents. Among these, influenza viruses play a key role, as they potentially cause severe respiratory distress, representin ...

2024

Beyond the limiting gap length: peripheral nerve regeneration through implantable nerve guidance conduits

Silvestro Micera, Francesco Stellacci

Peripheral nerve damage results in the loss of sensorimotor and autonomic functions, which is a significant burden to patients. Furthermore, nerve injuries greater than the limiting gap length require surgical repair. Although autografts are the preferred ...

Royal Soc Chemistry2024

A Synthetic Multivalent Lipopeptide Derived from Pam3CSK4 with Irreversible Influenza Inhibition and Immuno-Stimulating Effects

Francesco Stellacci, Li Tang, Bruno Emanuel Ferreira De Sousa Correia, Quy Ong Khac, Francesca Olgiati, Pablo Gainza Cirauqui, Lixia Wei, Armand Kurum, Yong Zhu

The activation of the host adaptive immune system is crucial for eliminating viruses. However, influenza infection often suppresses the innate immune response that precedes adaptive immunity, and the adaptive immune responses are typically delayed. Dendrit ...

Wiley-V C H Verlag Gmbh2024

Broad-Spectrum Supramolecularly Reloadable Antimicrobial Coatings

Francesco Stellacci, Francesca Olgiati, Heyun Wang, Matteo Gasbarri, Lukasz Richter

Antimicrobial surfaces limit the spread of infectious diseases. To date, there is no antimicrobial coating that has widespread use because of short-lived and limited spectrum efficacy, poor resistance to organic material, and/or cost. Here, we present a pa ...

Amer Chemical Soc2024

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Modulating Weak Protein-Protein Cross-Interactions by the Addition of Free Amino Acids at Millimolar Concentrations

Francesco Stellacci, Cécilia Laetitia Carla Siri, Pamina Winkler

2024

Development of Broad-Spectrum β-Cyclodextrins-Based Nanomaterials Against Influenza Viruses

Francesco Stellacci, Paulo Henrique Jacob Silva, Yong Zhu

2024

A Synthetic Multivalent Lipopeptide Derived from Pam3CSK4 with Irreversible Influenza Inhibition and Immuno-Stimulating Effects

Francesco Stellacci, Li Tang, Bruno Emanuel Ferreira De Sousa Correia, Quy Ong Khac, Francesca Olgiati, Pablo Gainza Cirauqui, Lixia Wei, Armand Kurum, Yong Zhu

Wiley-V C H Verlag Gmbh2024

Combining external physical stimuli and nanostructured materials for upregulating pro-regenerative cellular pathways in peripheral nerve repair

Silvestro Micera, Francesco Stellacci

FRONTIERS MEDIA SA2024