Jocelin Grosse

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Publications associées (28)

Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress

Rolf Gruetter, Maria del Carmen Sandi Perez, Bart Deplancke, Jocelin Grosse, Daniel Alpern, Julie Marie Russeil, Meltem Weger, Antoine Timothée Cherix, Sriparna Ghosal

Mitochondrial dysfunction was highlighted as a crucial vulnerability factor for the development of depression. However, systemic studies assessing stress-induced changes in mitochondria-associated genes in brain regions relevant to depression symptomatolog ...

2020

The glucocorticoid receptor in the nucleus accumbens plays a crucial role in social rank attainment in rodents

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Fiona Hollis, Ioannis Zalachoras, Meltem Weger, Thomas Didier Larrieu, Alexandre Claude Gustave Bacq

Social hierarchy in social species is usually established through competitive encounters with conspecifics. It determines the access to limited resources and, thus, leads to reduced fights among individuals within a group. Despite the known importance of s ...

2020

Astrocytic release of ATP through type 2 inositol 1,4,5‐trisphosphate receptor calcium signaling and social dominance behavior in mice

Maria del Carmen Sandi Perez, Jocelin Grosse, Marie-Isabelle Guillot de Suduiraut, Fiona Hollis, Eva Ramos Fernandez

Brain mitochondrial function is critical for numerous neuronal processes. We recently identified a link between brain energy and social dominance, where higher levels of mitochondrial function resulted in increased social competitive ability. The underlyin ...

2020

Low vagal tone in two rat models of psychopathology involving high or low corticosterone stress responses

Maria del Carmen Sandi Perez, Damien Sébastien Huzard, Jocelin Grosse, Sriparna Ghosal

The two stress-responsive physiological systems, autonomic nervous system (ANS) and hypothalamus-pituitary-adrenal (HPA) axis exert complementary and interrelated actions in the organism. Individuals that suffer stress-related psychopathologies frequently ...

2019

Peripubertal stress-induced heightened aggression: modulation of the glucocorticoid receptor in the central amygdala and normalization by mifepristone treatment

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Stamatina Tzanoulinou, Orbicia Riccio Wicht, Vandana Veenit

Despite the enormous negative impact of excessive aggression for individuals and societies, there is a paucity of treatments. Here, using a peripubertal stress model of heightened aggression in rats, we investigated the involvement of the glucocorticoid sy ...

2019

Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy

Cristina Ramona Cudalbu, Katarzyna Pierzchala, Jocelin Grosse, Veronika Rackayová

Background & Aims: The sequence of events in hepatic encephalopathy (HE) remains unclear. Using the advantages of in vivo 1H-MRS (9.4T) we aimed to analyse the time-course of disease in an established model of type C HE by analysing the longitudinal change ...

2019

Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of accumbal dopamine D1 receptors

Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Fiona Hollis, Jocelin Grosse, Ioannis Zalachoras, Olivia Zanoletti, Marie-Isabelle Guillot de Suduiraut, Michael van der Kooij, Laura Lozano Montes, Sonia Abad Florensa

Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines’ effects in social competition are not understood. Convergi ...

Nature Publishing Group2018

Increased brain glucocorticoid actions following social defeat in rats facilitates the long-term establishment of social subordination

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Meltem Weger

Social rank is frequently established through aggressive encounters between new conspecifics. Despite increasing evidence suggesting that social rank is critical for the well-being of both humans and animals, knowledge about the factors influencing social ...

2018

Peripubertal stress increases play fighting at adolescence and modulates nucleus accumbens CB1 receptor expression and mitochondrial function in the amygdala

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti

Play fighting is a highly rewarding behavior that helps individuals to develop social skills. Early-life stress has been shown to alter play fighting in rats and hamsters as well as to increase aggressive behaviors at adulthood. However, it is not known wh ...

2018

Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency

Graham Knott, Maria del Carmen Sandi Perez, Johannes Gräff, Jocelin Grosse, Olivia Zanoletti, Simone Astori, Elias Georges Gebara, Jose Vicente Sanchez Mut, Catherine Maclachlan, Wei Tang

Aggression is frequently observed in neurodevelopmental psychiatric disorders such as schizophrenia, autism, and bipolar disorder. Due to a lack of understanding of its underlying mechanisms, effective treatments for abnormal aggression are still missing. ...

2020

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