Publications de Yun Wang | EPFL Graph Search

Relative Effects of the Hospital Readmissions Reduction Program on Hospitals That Serve Poorer Patients

Importance: Hospitals that serve poorer populations have higher readmission rates. It is unknown whether these hospitals effectively lowered readmission rates in response to the Hospital Readmissions Reduction Program (HRRP). Objective: To compare pre-post ...

2019

Short term exposure to fine particulate matter and hospital admission risks and costs in the Medicare population: time stratified, case crossover study

Yun Wang, Christine Choirat

OBJECTIVE To assess risks and costs of hospital admission associated with short term exposure to fine particulate matter with diameter less than 2.5 mu m (PM2.5) for 214 mutually exclusive disease groups. DESIGN Time stratified, case crossover analyses wit ...

BMJ2019

Objective Morphological Classification of Neocortical Pyramidal Cells

Henry Markram, Kathryn Hess Bellwald, Srikanth Ramaswamy, Rodrigo de Campos Perin, Lida Kanari, Ying Shi, Julie Meystre, Marwan Muhammad Ahmed Abdellah, Yun Wang

A consensus on the number of morphologically different types of pyramidal cells (PCs) in the neocortex has not yet been reached, despite over a century of anatomical studies, due to the lack of agreement on the subjective classifications of neuron types, w ...

Oxford University Press (OUP)2019

The neocortical microcircuit collaboration portal: a resource for rat somatosensory cortex

Henry Markram, Sean Lewis Hill, Lida Kanari, Eilif Benjamin Muller, Srikanth Ramaswamy, Ying Shi, Rajnish Ranjan, Michael Reimann, Felix Schürmann, James Gonzalo King

We have established a multi-constraint, data-driven process to digitally reconstruct, and simulate prototypical neocortical microcircuitry, using sparse experimental data. We applied this process to reconstruct the microcircuitry of the somatosensory corte ...

Frontiers Research Foundation2015

Reconstruction and Simulation of Neocortical Microcircuitry

Anastasia Ailamaki, Henry Markram, Sean Lewis Hill, Eilif Benjamin Muller, Rodrigo de Campos Perin, Lida Kanari, Srikanth Ramaswamy, Vincent Delattre, Michael Reimann, Ying Shi

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse ex ...

Elsevier2015

Synaptic and cellular organization of layer 1 of the developing rat somatosensory cortex

Henry Markram, Shruti Muralidhar, Yun Wang

Layer 1 of the neocortex is sparsely populated with neurons and heavily innervated by fibers from lower layers and proximal and distal brain regions. Understanding the potential functions of this layer requires a comprehensive understanding of its cellular ...

Frontiers Research Foundation2014

New insights into the classification and nomenclature of cortical GABAergic interneurons

Henry Markram, Sean Lewis Hill, Yun Wang, Ruth Benavides Piccione, Jean Rossier, Zoltan Kisvarday

A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxononnical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based ...

Nature Publishing Group2013

Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits

Henry Markram, Felix Schürmann, Yun Wang, Imad Riachi

It is well-established that synapse formation involves highly selective chemospecific mechanisms, but how neuron arbors are positioned before synapse formation remains unclear. Using 3D reconstructions of 298 neocortical cells of different types (including ...

Natl Acad Sciences2012

Intrinsic morphological diversity of thick-tufted layer 5 pyramidal neurons ensures robust and invariant properties of in silico synaptic connections

Henry Markram, Felix Schürmann, Srikanth Ramaswamy, Yun Wang

The morphology of neocortical pyramidal neurons is not only highly characteristic but also displays an intrinsic diversity that renders each neuron morphologically unique. We investigated the significance of this intrinsic morphological diversity in in sil ...

2012

Morphological development of thick-tufted layer v pyramidal cells in the rat somatosensory cortex

Henry Markram, Yun Wang, Sandrine Romand

The thick-tufted layer V pyramidal (TTL5) neuron is a key neuron providing output from the neocortex. Although it has been extensively studied, principles governing its dendritic and axonal arborization during development are still not fully quantified. Us ...

2011