Publications de Samira Asgari | EPFL Graph Search

Whole-exome Sequencing for the Identification of Rare Variants in Primary Immunodeficiency Genes in Children With Sepsis: A Prospective, Population-based Cohort Study

Jacques Fellay, Christian Axel Wandall Thorball, Alessandro Borghesi, Nimisha Chaturvedi, Samira Asgari

Background. The role of primary immunodeficiencies (PID) in susceptibility to sepsis remains unknown. It is unclear whether children with sepsis benefit from genetic investigations. We hypothesized that sepsis may represent the first manifestation of under ...

OXFORD UNIV PRESS INC2020

Rare variants in antiviral response genes drive severe viral respiratory infections in children

Jacques Fellay, Dylan Lawless, Samira Asgari

NATURE PUBLISHING GROUP2019

Human genomics of acute liver failure due to hepatitis B virus infection: An exome sequencing study in liver transplant recipients

Jacques Fellay, Christian Hammer, Nimisha Chaturvedi, Petar Scepanovic, Samira Asgari

Acute liver failure (ALF) or fulminant hepatitis is a rare, yet severe outcome of infection with hepatitis B virus (HBV) that carries a high mortality rate. The occurrence of a life-threatening condition upon infection with a prevalent virus in individuals ...

2019

Severe viral respiratory infections in children with IFIH1 loss-of-function mutations

Jacques Fellay, Amalio Telenti, Istvan Bartha, Christian Hammer, Samira Asgari, Thomas Junier, Paul Jack Mc Laren

Viral respiratory infections are usually mild and self-limiting; still they exceptionally result in life-threatening infections in previously healthy children. To investigate a potential genetic cause, we recruited 120 previously healthy children requiring ...

Natl Acad Sciences2017

Exome Sequencing Reveals Primary Immunodeficiencies in Children with Community-Acquired Pseudomonas aeruginosa Sepsis

Jacques Fellay, Istvan Bartha, Samira Asgari, Christoph Berger, Paul Jack Mc Laren, Richard Wong

One out of three pediatric sepsis deaths in high income countries occur in previously healthy children. Primary immunodeficiencies (PIDs) have been postulated to underlie fulminant sepsis, but this concept remains to be confirmed in clinical practice. Pseu ...

Frontiers Media Sa2016

Corrigendum: Exome Sequencing reveals Primary immunodeficiencies in Children with Community-Acquired Pseudomonas aeruginosa Sepsis (vol 7, 357, 2016)

Jacques Fellay, Istvan Bartha, Samira Asgari, Christoph Berger, Paul Jack Mc Laren, Richard Wong

Frontiers Media Sa2016

Host and pathogen genomics of severe pediatric infections

Samira Asgari

Infectious diseases are among the leading causes of human morbidity and mortality, with the greatest burden felt in the pediatric population. For any infectious disease, only a fraction of the exposed individuals develop clinical symptoms. These inter-indi ...

EPFL2016