Publications de Sébastien Mosser

Endogenous Regulators of Gamma-Secretase and Amyloid-Beta Production, and Engineering of Alzheimer's Disease Therapeutic Tools

Alzheimer s disease (AD) is a devastating neurodegenerative disease characterized by strong cognitive impairment and memory loss. These symptoms are caused by neuronal death, induced by two pathological hallmarks: extracellular senile plaques composed of a ...

EPFL2016

Identification of new Presenilin-1 phosphosites: implication for gamma-secretase activity and A beta production

Patrick Fraering, Romain Hamelin, Mitko Dimitrov, Marc Moniatte, Sébastien Mosser, Alexandre Matz, Blanka Halamoda

An important pathological hallmark of Alzheimer's disease (AD) is the deposition of amyloid-beta (A) peptides in the brain parenchyma, leading to neuronal death and impaired learning and memory. The protease -secretase is responsible for the intramembrane ...

Wiley-Blackwell2015

The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain

Bernard Schneider, Patrick Fraering, Mitko Dimitrov, Sébastien Mosser, Justine Pascual, Alexandre Matz

The deposition of amyloid-beta (Aβ) aggregates in the brain is a major pathological hallmark of Alzheimer's disease (AD). Aβ is generated from the cleavage of C-terminal fragments of the amyloid precursor protein (APP-CTFs) by γ-secretase, an intramembrane ...

Oxford University Press2015

A Simple and Reliable PDMS and SU-8 Irreversible Bonding Method and Its Application on a Microfluidic-MEA Device for Neuroscience Research

Philippe Renaud, Arnaud Bertsch, Marc Olivier Heuschkel, Patrick Fraering, Sébastien Mosser, Yufei Ren, Shun-Ho Huang, Jingjing Chen

Polydimethylsiloxane (PDMS) and SU-8 are currently two very commonly used polymeric materials in the microfluidics field for biological applications. However; there is a pressing need to find a simple, reliable, irreversible bonding method between these tw ...

MDPI2015

Mimicking Alzheimer's disease spreading via an integrated microfluidics-MEA device in vitro

Philippe Renaud, Marc Olivier Heuschkel, Patrick Fraering, Sébastien Mosser, Yufei Ren, Jingjing Chen

2015

Detection of Alzheimer’s disease amyloid-beta plaque deposition by deep brain impedance profiling

Philippe Renaud, Patrick Fraering, Sébastien Mosser, Pierre Joris, Amélie Barbara Hildegarde Béduer

OBJECTIVE: Alzheimer disease (AD) is the most common form of neurodegenerative disease in elderly people. Toxic brain amyloid-beta (ASS) aggregates and ensuing cell death are believed to play a central role in the pathogenesis of the disease. In this study ...

Iop Publishing Ltd2015

A Compressible Scaffold for Minimally Invasive Delivery of Large Intact Neuronal Networks

Philippe Renaud, Georg Fantner, Thomas Michael Braschler, Patrick Fraering, Oliver Peric, Sébastien Mosser, Amélie Barbara Hildegarde Béduer, Sidi Ahmed Bencherif

Millimeter to centimeter-sized injectable neural scaffolds based on macroporous cryogels are presented. The polymer-scaffolds are made from alginate and carboxymethyl-cellulose by a novel simple one-pot cryosynthesis. They allow surgical sterility by means ...

Wiley-VCH Verlag2015

Inactivation of brain Cofilin-1 by age, Alzheimer's disease and gamma-secretase

Patrick Fraering, Sébastien Mosser, Eugenio Barone

Rapid remodeling of the actin cytoskeleton in the pre- and/or post-synaptic compartments is responsible for the regulation of neuronal plasticity, which is an important process for learning and memory. Cofilin1 plays an essential role in these processes an ...

Elsevier Science Bv2014

Accurate resistivity mouse brain mapping using microelectrode arrays

Philippe Renaud, Vincent Delattre, Patrick Fraering, Sébastien Mosser, Pierre Joris, Amélie Barbara Hildegarde Béduer

Electrical impedance spectroscopy measurements were performed in post-mortem mice brains using a flexible probe with an embedded micrometric electrode array. Combined with a peak resistance frequency method this allowed obtaining intrinsic resistivity valu ...

Elsevier2014