Publications de Jean-Noël Hyacinthe

Tracking Hyperpolarized [1-¹³C] Pyruvate and [1-¹³C] L-Lactate Metabolism in the Healthy and Post-Stroke Mouse Brain

Rolf Gruetter, Bernard Lanz, Mor-Miri Mishkovsky, Jean-Noël Hyacinthe, Mario Gaetano Lepore, Thanh Phong Kevin Lê, Lara Buscemi Estefanell, Elise Marie Catherine Vinckenbosch

Tracking hyperpolarized (HP) ¹³C labeling from either [1-¹³C] pyruvate or [1-¹³C] lactate is a useful tool to assess intermediary metabolism in vivo, which has already been translated from preclinical to clinical research. HP [1-¹³C] pyruvate and [1-¹³C] l ...

Wiley2025

129Xe Dynamic Nuclear Polarization Demystified: The Influence of the Glassing Matrix on the Radical Properties

Rolf Gruetter, Andrea Capozzi, Jean-Noël Hyacinthe, Thanh Phong Kevin Lê, Emma Linnea Wiström

129Xe dissolution dynamic nuclear polarization (DNP) is a controversial topic. The gold standard technique for hyperpolarized xenon magnetic resonance imaging (MRI) is spin exchange optical pumping, which received FDA approval in 2022. Nevertheless, the ve ...

2024

Multi-sample/multi-nucleus parallel polarization and monitoring enabled by a fluid path technology compatible cryogenic probe for dissolution dynamic nuclear polarization

Andrea Capozzi, Jean-Noël Hyacinthe, Thanh Phong Kevin Lê

Low throughput is one of dissolution Dynamic Nuclear Polarization (dDNP) main shortcomings. Especially for clinical and preclinical applications, where direct 13C nuclei polarization is usually pursued, it takes hours to generate one single hyperpolarized ...

Nature Research2023

Influence of DNP Polarizing Agents on Biochemical Processes: TEMPOL in Transient Ischemic Stroke

Mor-Miri Mishkovsky, Jean-Noël Hyacinthe, Mario Gaetano Lepore, Thanh Phong Kevin Lê, Lara Buscemi Estefanell

Hyperpolarization of 13C by dissolution dynamic nuclear polarization (dDNP) boosts the sensitivity of magnetic resonance spectroscopy (MRS), making possible the monitoring in vivo and in real time of the biochemical reactions of exogenously infused 13C-lab ...

2023

How to improve the efficiency of a traditional dissolution dynamic nuclear polarization (dDNP) apparatus: Design and performance of a fluid path compatible dDNP/LOD-ESR probe

Andrea Capozzi, Jean-Noël Hyacinthe, Thanh Phong Kevin Lê

Dissolution Dynamic Nuclear Polarization (dDNP) was invented almost twenty years ago. Ever since, hardware advancement has observed 2 trends: the quest for DNP at higher field and, more recently, the development of cryogen free polarizers. Despite the DNP ...

Academic Press Inc - Elsevier Science2022

Evaluating the potential of hyperpolarised [1-13C] L-lactate as a neuroprotectant metabolic biosensor for stroke

Mor-Miri Mishkovsky, Mario Gaetano Lepore, Jean-Noël Hyacinthe, Thanh Phong Kevin Lê, Lara Buscemi Estefanell

Cerebral metabolism, which can be monitored by magnetic resonance spectroscopy (MRS), changes rapidly after brain ischaemic injury. Hyperpolarisation techniques boost (13)C MRS sensitivity by several orders of magnitude, thereby enabling in vivo monitoring ...

Nature Research2020

Optimal Glass-Forming Solvent Brings Sublimation Dynamic Nuclear Polarization to 129Xe Hyperpolarization Biomedical Imaging Standards

Christophe Roussel, Andrea Capozzi, Jean-Noël Hyacinthe, Arnaud Comment

In addition to the dedicated spin exchange optical pumping (SEOP) technique, an alternative method to produce hyperpolarized xenon gas using dynamic nuclear polarization (DNP) followed by a sublimation procedure was proposed. The challenge associated with ...

American Chemical Society2015

Photoinduced Nonpersistent Radicals as Polarizing Agents for X-Nuclei Dissolution Dynamic Nuclear Polarization

Giovanni Boero, Christophe Roussel, Andrea Capozzi, Jean-Noël Hyacinthe, Tian Cheng, Arnaud Comment, Jacques Van Der Klink, Tim Rolf Eichhorn

Hyperpolarization via dissolution dynamic nuclear polarization (DNP) is a versatile method to dramatically enhance the liquid-state NMR signal of X-nuclei and can be used for performing metabolic and molecular imaging. It was recently demonstrated that ins ...

American Chemical Society2015

In vivo real-time metabolic imaging using frequency selective bSSFP and hyperpolarized compounds

Andrea Capozzi, Jean-Noël Hyacinthe, Arnaud Comment, Najat Salameh

2014

Hyperpolarization of 129Xe by sublimation DNP using photo-activated radical precursors

Christophe Roussel, Andrea Capozzi, Jean-Noël Hyacinthe, Arnaud Comment, Najat Salameh, Tim Rolf Eichhorn, François Lazeyras

2013