Publications de Marco Bonizzato

Introducing a biomimetic coating for graphene neuroelectronics: toward in-vivo applications

Grégoire Courtine, Quentin Barraud, Marco Bonizzato, Elodie Rey

Electronic micro and nano-devices are suitable tools to monitor the activity of many individual neurons over mesoscale networks. However the inorganic materials currently used in microelectronics are barely accepted by neural cells and tissues, thus limiti ...

IOP PUBLISHING LTD2021

Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury

Silvestro Micera, Marco Bonizzato

A spinal cord injury usually spares some components of the locomotor circuitry. Deep brain stimulation (DBS) of the midbrain locomotor region and epidural electrical stimulation of the lumbar spinal cord (EES) are being used to tap into this spared circuit ...

Nature Research2021

Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury

Silvestro Micera, Marco Bonizzato, Grégoire Courtine, Polina Shkorbatova, Natalia Pavlova, Galyna Pidpruzhnykova

The delivery of brain-controlled neuromodulation therapies during motor rehabilitation may augment recovery from neurological disorders. To test this hypothesis, we conceived a brain-controlled neuromodulation therapy that combines the technical and practi ...

Nature Publishing Group2018

System to deliver adaptive epidural and/or subdural electrical spinal cord stimulation to facilitate and restore locomotion after a neuromotor impairment

Silvestro Micera, Grégoire Courtine, Eduardo Martin Moraud, Nikolaus Wenger, Marco Bonizzato

The present disclosure provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively co ...

2018

Brain-controlled neuroprosthetic interventions to restore locomotion after contusion spinal cord injury in the rat

Marco Bonizzato

Spinal cord injury (SCI), second only to stroke, is the leading cause of paralysis. Therapies based on electrical stimulation of the spinal cord and other locomotor areas of the Nervous System improve motor control in people with neurotrauma. Neuromodulati ...

EPFL2017

Bidirectional Limb Neuro-Prosthesis

Silvestro Micera, Marco Capogrosso, Stanisa Raspopovic, Francesco Maria Petrini, Marco Bonizzato

Integrated closed-loop real-time limb neuro-prosthetic system comprising an artificial limb, a microprocessor, sensors, a signal conditioner, a stimulator, at least one EMG electrode and at least one sensory feedback electrode, characterized by the fact th ...

2016

System to deliver adaptive epidural and/or subdural electrical spinal cord stimulation to facilitate and restore locomotion after a neuromotor impairment

Silvestro Micera, Grégoire Courtine, Eduardo Martin Moraud, Nikolaus Wenger, Marco Bonizzato

The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively co ...

2016

Corticospinal neuroprostheses to restore locomotion after spinal cord injury

José del Rocio Millán Ruiz, Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Eduardo Martin Moraud, Pavel Musienko, Nikolaus Wenger, Ivan Rusev Minev, Marco Bonizzato, Janine Beauparlant

In this conceptual review, we highlight our strategy for, and progress in the development of corticospinal neuroprostheses for restoring locomotor functions and promoting neural repair after thoracic spinal cord injury in experimental animal models. We spe ...

Elsevier2014

Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury

Silvestro Micera, Grégoire Courtine, Eduardo Martin Moraud, Stanisa Raspopovic, Pavel Musienko, Nikolaus Wenger, Marco Bonizzato

Neuromodulation of spinal sensorimotor circuits improves motor control in animal models and humans with spinal cord injury. With common neuromodulation devices, electrical stimulation parameters are tuned manually and remain constant during movement. We de ...

American Association for the Advancement of Science2014

Restoring Natural Sensory Feedback in Real-Time Bidirectional Hand Prostheses

Silvestro Micera, Marco Capogrosso, Stanisa Raspopovic, Francesco Maria Petrini, Jacopo Rigosa, Marco Bonizzato

Hand loss is a highly disabling event that markedly affects the quality of life. To achieve a close to natural replacement for the lost hand, the user should be provided with the rich sensations that we naturally perceive when grasping or manipulating an o ...

American Association for the Advancement of Science2014