Publications de Rubia van den Brand

A multidirectional gravity-assist algorithm that enhances locomotor control in patients with stroke or spinal cord injury

Auke Ijspeert, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Selin Anil, Joachim von Zitzewitz, Nicolas Francis Fumeaux, Jessica Lanini, Rubia van den Brand, Jean-Baptiste Mignardot

Gait recovery after neurological disorders requires remastering the interplay between body mechanics and gravitational forces. Despite the importance of gravity-dependent gait interactions and active participation for promoting this learning, these essenti ...

Amer Assoc Advancement Science2017

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Jocelyne Bloch, Marco Capogrosso, Eduardo Martin Moraud, Pavel Musienko, Nikolaus Wenger, Natalia Pavlova

Electrical neuromodulation of lumbar segments improves motor control after spinal cord injury in animal models and humans. However, the physiological principles underlying the effect of this intervention remain poorly understood, which has limited the ther ...

Nature Publishing Group2016

Engagement of the Rat Hindlimb Motor Cortex across Natural Locomotor Behaviors

Silvestro Micera, Grégoire Courtine, Rubia van den Brand, Jacopo Rigosa, Julie Kreider, Lucia Florinda Friedli Wittler, Janine Beauparlant, Simone Ellen Joze Duis

Contrary to cats and primates, cortical contribution to hindlimb locomotor movements is not critical in rats. However, the importance of the motor cortex to regain locomotion after neurological disorders in rats suggests that cortical engagement in hindlim ...

Soc Neuroscience2016

Rehabilitative Soft Exoskeleton for Rodents

Silvestro Micera, Grégoire Courtine, Jamie Paik, Eduardo Martin Moraud, Joachim von Zitzewitz, Sophie Marie Marthe Wurth, Rubia van den Brand, Juan Manuel Florez Marin, Laetitia Danielle Philippine Baud, Manan Kishore Shah

Robotic exoskeletons provide programmable, consistent and controllable active therapeutic assistance to patients with neurological disorders. Here we introduce a prototype and preliminary experimental evaluation of a rehabilitative gait exoskeleton that en ...

Institute of Electrical and Electronics Engineers2016

Decoding bipedal locomotion from the rat sensorimotor cortex

Silvestro Micera, Grégoire Courtine, Rubia van den Brand, Jacopo Rigosa, Lucia Florinda Friedli Wittler

Objective. Decoding forelimb movements from the firing activity of cortical neurons has been interfaced with robotic and prosthetic systems to replace lost upper limb functions in humans. Despite the potential of this approach to improve locomotion and fac ...

Institute of Physics2015

Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury

Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Joachim von Zitzewitz, Nicolas Francis Fumeaux, Marco Capogrosso, Rubia van den Brand, Fabien Bertrand Paul Wagner, Jean-Baptiste Mignardot

Spinal cord injury leads to a range of disabilities, including limitations in locomotor activity, that seriously diminish the patients’ autonomy and quality of life. Electrochemical neuromodulation therapies, robot-assisted rehabilitation and willpower-bas ...

2015

Undirected compensatory plasticity contributes to neuronal dysfunction after severe spinal cord injury

Grégoire Courtine, Quentin Barraud, Pavel Musienko, Rubia van den Brand, Lucia Florinda Friedli Wittler, Janine Beauparlant

Severe spinal cord injury in humans leads to a progressive neuronal dysfunction in the chronic stage of the injury. This dysfunction is characterized by premature exhaustion of muscle activity during assisted locomotion, which is associated with the emerge ...

Oxford University Press2013

Multisystem Neuroprosthetic Training Improves Bladder Function After Severe Spinal Cord Injury

Grégoire Courtine, Janine Beauparlant, Rubia van den Brand, Daniel Eberli

Severe spinal cord injury leads to neurogenic bladder dysfunction. We recently developed a multisystem neuroprosthetic training program that promotes plastic changes capable of restoring refined locomotion in rats with severe spinal cord injury. We investi ...

Elsevier Science Inc2013

Soft Robot for Gait Rehabilitation of Spinalized Rodents

Silvestro Micera, Grégoire Courtine, Jamie Paik, Yi Sun, Joachim von Zitzewitz, Yun Seong Song, Rubia van den Brand

Soft actuators made of highly elastic polymers allow novel robotic system designs, yet application-specific soft robotic systems are rarely reported. Taking notice of the characteristics of soft pneumatic actuators (SPAs) such as high customizability and l ...

Ieee2013

Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders

Grégoire Courtine, Pavel Musienko, Rubia van den Brand, Lucia Florinda Friedli Wittler

Central nervous system (CNS) disorders distinctly impair locomotor pattern generation and balance, but technical limitations prevent independent assessment and rehabilitation of these subfunctions. Here we introduce a versatile robotic interface to evaluat ...

Nature Publishing Group2012