Publications de Marco Grisi | EPFL Graph Search

Micro magnetic resonance spectroscopy for noninvasive metabolic screening of mammalian embryos and oocytes

Analyzing cellular health and metabolism without compromising cell integrity is a major challenge. We present a noninvasive technique using micro magnetic resonance spectroscopy (micro MRS) for nondestructive metabolic fingerprinting at the single-cell sca ...

2025

NMR spectroscopy of a single mammalian early stage embryo

Jürgen Brugger, Giovanni Boero, Marco Grisi, Gaurasundar Marc Conley, Kyle Joel Rodriguez

The resolving power, chemical sensitivity and non-invasive nature of NMR have made it an established technique for in vivo studies of large organisms both for research and clinical applications. NMR would clearly be beneficial for analysis of entities at t ...

Academic Press Inc - Elsevier Science2022

Single chip dynamic nuclear polarization microsystem

Giovanni Boero, Marco Grisi, Nergiz Sahin Solmaz, Alessandro Valentino Matheoud, Gabriele Gualco

Integration of the sensitivity-relevant electronics of nuclear magnetic resonance (NMR) and electron spin resonance (ESR) spectrometers on a single chip is a promising approach to improve the limit of detection, especially for samples in the nanoliter and ...

2020

Miniaturized mr device comprising a cell culture micro-chamber and method for manufacturing such a device

Jürgen Brugger, Giovanni Boero, Marco Grisi, Gaurasundar Marc Conley

MR device (100) comprising a miniaturized magnetic resonance system (101) and a cell culture chamber (502) for the analysis of biological samples of less than about 1000 µm in size, wherein said device (100) is at least partially covered by a passivation-b ...

2020

NMR microsystem for label-free characterization of 3D nanoliter microtissues

Jürgen Brugger, Giovanni Boero, Marco Grisi, Gaurasundar Marc Conley, Kyle Joel Rodriguez, Lukas Egli, Erika Riva

Performing chemical analysis at the nanoliter (nL) scale is of paramount importance for medicine, drug development, toxicology, and research. Despite the numerous methodologies available, a tool for obtaining chemical information non-invasively is still mi ...

Nature Research2020

CMOS and 3D Printing for NMR Spectroscopy at the Single Embryo Scale

Jürgen Brugger, Martinus Gijs, Giovanni Boero, Johann Michler, Nicola Harris, Franck Vincent, Marco Grisi, Enrica Montinaro, Beatrice Volpe, Maria Cristina Letizia

SWISS CHEMICAL SOC2019

A single-chip integrated transceiver for high field NMR magnetometry

Giovanni Boero, Marco Grisi, Gaurasundar Marc Conley

We present the design and performance of a broad-band single-chip integrated transceiver specifically conceived for nuclear magnetic resonance magnetometry. The single-chip transceiver is realized using a standard silicon complementary metal-oxide-semicond ...

AMER INST PHYSICS2019

3D printed microchannels for sub-nL NMR spectroscopy

Jürgen Brugger, Giovanni Boero, Martinus Gijs, Johann Michler, Marco Grisi, Enrica Montinaro, Maria Cristina Letizia, Laszlo Pethö

Nuclear magnetic resonance (NMR) experiments on subnanoliter (sub-nL) volumes are hindered by the limited sensitivity of the detector and the difficulties in positioning and holding such small samples in proximity of the detector. In this work, we report o ...

2018

NMR spectroscopy of single sub-nL ova with inductive ultra-compact single-chip probes

Giovanni Boero, Franck Vincent, Marco Grisi, Nicola Harris, Beatrice Volpe

Nuclear magnetic resonance (NMR) spectroscopy enables non-invasive chemical studies of intact living matter. However, the use of NMR at the volume scale typical of microorganisms is hindered by sensitivity limitations, and experiments on single intact orga ...

Nature Research2017

Broadband IQ CMOS transceivers for compact and ultra-compact NMR probes

Giovanni Boero, Marco Grisi

2017