Publications de Julien Robert Rémi Faget

Activin-A impairs CD8 T cell-mediated immunity and immune checkpoint therapy response in melanoma

Daniel Constam, Etienne Meylan, Julien Robert Rémi Faget, Olivier Andreas Dubey, Katarina Pinjusic

Background Activin-A, a transforming growth factor beta family member, is secreted by many cancer types and is often associated with poor disease prognosis. Previous studies have shown that Activin-A expression can promote cancer progression and reduce the ...

BMJ PUBLISHING GROUP2022

Neutrophils in the era of immune checkpoint blockade

Etienne Meylan, Julien Robert Rémi Faget

The immune checkpoint blockade-based immunotherapies are revolutionizing cancer management. Tumor-associated neutrophils (TANs) were recently highlighted to have a pivotal role in modulating the tumor microenvironment and the antitumor immune response. How ...

BMJ PUBLISHING GROUP2021

Low-dose photodynamic therapy promotes a cytotoxic immunological response in a murine model of pleural mesothelioma

Paul Joseph Dyson, Etienne Meylan, Julien Robert Rémi Faget, Aspasia Gkasti, Yameng Hao, Maxime Reichenbach

OBJECTIVES: Malignant pleural mesothelioma (MPM) is a deadly disease with limited treatment options. Approaches to enhance patient immunity against MPM have been tested but shown variable results. Previously, we have demonstrated interesting vascular modul ...

OXFORD UNIV PRESS INC2020

Mechanisms Of Lung Cancer Hyper-Progression Promoted By Pd-1 Immune Checkpoint Blockade

Etienne Meylan, Julien Robert Rémi Faget, Amaia Martinez Usatorre

BMJ PUBLISHING GROUP2020

Durable and controlled depletion of neutrophils in mice

Etienne Meylan, Julien Robert Rémi Faget, Gael Luis Boivin, Caroline Anne-Lyse Contat, Jessica Christine Vazquez, Justine Pascual, Pierre-Benoit Bernard Ancey, Aspasia Gkasti

Neutrophils are an essential part of the innate immune system. To study their importance, experimental studies often aim to deplete these cells, generally by injecting anti-Ly6G or anti-Gr1 antibodies. However, these approaches are only partially effective ...

Nature Research2020

Low dose photodynamic therapy promotes a cytotoxic immunological response in a murine model of malignant pleural mesothelioma

Etienne Meylan, Julien Robert Rémi Faget, Yan Hao, Carsten Hao Ye Chong, Aspasia Gkasti

WILEY2019

RANKL Signaling Sustains Primary Tumor Growth in Genetically Engineered Mouse Models of Lung Adenocarcinoma

Nadine Fournier, Etienne Meylan, Julien Robert Rémi Faget, Caroline Anne-Lyse Contat

INTRODUCTION: NSCLC is the leading cause of cancer mortality. Recent retrospective clinical analyses suggest that blocking the receptor activator of NF-κB (RANK) signaling pathway inhibits the growth of NSCLC and might represent a new treatment strategy. M ...

2018

Snail mediates repression of the Dlk1-Dio3 locus in lung tumor-infiltrating immune cells

Nadine Fournier, Etienne Meylan, Svenja Johanna Groeneveld, Julien Robert Rémi Faget

The epithelial-mesenchymal transition-inducing transcription factor Snail contributes to tumor progression in different malignancies. In the present study, we used a transcriptomics approach to elucidate the mechanism of Snail-mediated tumor growth promoti ...

2018

Neutrophils and Snail orchestrate the establishment of a protumor microenvironment in lung adenocarcinoma

Nicolas Jean Philippe Guex, Nadine Fournier, Etienne Meylan, Miguel Garcia, Julien Robert Rémi Faget, Svenja Johanna Groeneveld, Alessandra Piersigilli, Inti Zlobec, Gael Luis Boivin, Ioannis Xenarios

AMER ASSOC CANCER RESEARCH2018

Cellular Composition and Contribution of Tertiary Lymphoid Structures to Tumor Immune Infiltration and Modulation by Radiation Therapy

Etienne Meylan, Julien Robert Rémi Faget, Gael Luis Boivin

2018