Tzu-En Lin

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Publications associées (21)

Microfluidic Probes for Scanning Electrochemical Microscopy

Hubert Girault, Andreas Stephan Lesch, Fernando Cortes Salazar, Tzu-En Lin, Alexandra Bondarenko

This chapter discusses the soft microfluidic scanning electrochemical microscopy (SECM) probes represent a versatile tool for supporting various investigations ranging from the electrochemical characterization of different surfaces to the local perturbatio ...

Wiley2018

Electrochemical Imaging of Cells and Tissues

Hubert Girault, Tzu-En Lin, Andreas Stephan Lesch

The technological and experimental progress in electrochemical imaging of biological specimens is discussed with a view on potential applications for skin cancer diagnostics, reproductive medicine and microbial testing. The electrochemical analysis of sing ...

2018

Soft probes for bio-electrochemical imaging

Tzu-En Lin

The aim of bioimaging is to visualize properties and processes of living objects or biological samples and extracts image-related information for revealing important physical structures or map the distribution of specific biomolecules in tissues for clinic ...

EPFL2017

Electrostatic spray ionization from 384-well microtiter plates for mass spectrometry analysis based enzyme assay and drug metabolism screening

Hubert Girault, Liang Qiao, Tzu-En Lin, Elena Tobolkina, Xiaoqin Zhong, Yan Deng, Emna Belghith

We have realized the direct ionization of samples from wells of microtiter plates under atmospheric conditions for mass spectrometry analysis without any liquid delivery system or any additional interface. The microtiter plate is a commercially available 3 ...

American Chemical Society2017

Weiche elektrochemische Sonden zum Abbilden der Verteilung von Biomarkern und injizierten Nanomaterialien in tierischem und menschlichem Gewebe

Hubert Girault, Horst Pick, Andreas Stephan Lesch, Tzu-En Lin, Yu Lu

Die Untersuchung von Biomarkern und injizierten theranostischen Nanomaterialien in Geweben und Organen spielt eine zentrale Rolle bei zahlreichen medizinischen Verfahren von der Krebsdiagnose bis hin zur Arzneimittelverabreichung. Zu diesem Zweck kann die ...

Wiley-Blackwell2017

Mapping the antioxidant activity of apple peels with soft probe scanning electrochemical microscopy

Hubert Girault, Andreas Stephan Lesch, Tzu-En Lin

We present a non-invasive electrochemical strategy for mapping the antioxidant (AO) activity of apple peels, which counterbalances oxidative stress caused by various external effectors. Soft carbon microelectrodes were used for soft probe scanning electroc ...

Elsevier Science Sa2017

Soft Electrochemical Probes for Mapping the Distribution of Biomarkers and Injected Nanomaterials in Animal and Human Tissues

Hubert Girault, Horst Pick, Andreas Stephan Lesch, Tzu-En Lin, Yu Lu

Monitoring biomarkers and injected theranostic nanomaterials in tissues and organs plays a pivotal role in numerous medical applications ranging from cancer diagnostics to drug delivery. Scanning electrochemical microscopy has been demonstrated as a powerf ...

Wiley-Blackwell2017

Monitoring Tyrosinase Expression in Non-metastatic and Metastatic Melanoma Tissues by Scanning Electrochemical Microscopy

Hubert Girault, Horst Pick, Andreas Stephan Lesch, Fernando Cortes Salazar, Tzu-En Lin, Alexandra Bondarenko

Although tremendous progress has been made in the diagnosis of melanoma, the identification of different stages of malignancy in a reliable way remains challenging. Current strategies rely on optical monitoring of the concentration and spatial distribution ...

Wiley-Blackwell2016

Fixation and Permeabilization Approaches for Scanning Electrochemical Microscopy of Living Cells

Hubert Girault, Horst Pick, Andreas Stephan Lesch, Fernando Cortes Salazar, Tzu-En Lin, Alexandra Bondarenko, Petar Stupar

Scanning electrochemical microscopy (SECM) has been widely used for the electrochemical imaging of dynamic topographical and metabolic changes in alive adherent mammalian cells. However, extracting intracellular information by SECM is challenging, since it ...

American Chemical Society2016

Untersuchung der Tyrosinase-Expression in nicht-metastatischen und metastatischen Melanomgeweben durch elektrochemische Rastersondenmikroskopie

Hubert Girault, Horst Pick, Andreas Stephan Lesch, Tzu-En Lin, Fernando Cortes Salazar, Alexandra Bondarenko

Trotz des enormen Fortschritts, der bei der Diagnose von Melanomen erzielt wurde, bleibt die zuverlässige Erkennung der verschiedenen Malignomstadien eine Herausforderung. Derzeitige Strategien setzen auf die optische Erfassung der Konzentration und räumli ...

Wiley-Blackwell2016

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