Publications de Julia Pedroni | EPFL Graph Search

Access to P- and Axially Chiral Biaryl Phosphine Oxides by Enantioselective (CpIrIII)-Ir-x-Catalyzed C-H Arylations

Nicolai Cramer, Julia Pedroni, Yun-Suk Jang

An enantioselective C-H arylation of phosphine oxides with o-quinone diazides catalyzed by an iridium(III) complex bearing an atropchiral cyclopentadienyl (Cp-x) ligand and phthaloyl tert-leucine as co-catalyst is reported. The method allows access to a) P ...

Wiley-VCH Verlag GmbH2018

Pd(0)-Catalysed C-H Functionalisations for the Enantioselective Synthesis of N-Heterocycles

Julia Pedroni

Transition-metal catalysed enantioselective Câ H functionalisations enable rapid increase of molecular complexity via non-classical disconnections. This thesis describes the development of intramolecular Pd(0)-catalysed C-H functionalisations for the asym ...

EPFL2017

Enantioselective C-H Functionalization-Addition Sequence Delivers Densely Substituted 3-Azabicyclo[3.1.0]hexanes

Nicolai Cramer, Julia Pedroni

An enantioselective C-H functioffalization route to perfluoroalkyl-containing 3-azabicyclo[3.1.0]-hexanes is disclosed. A modular and bench-stable diazaphospholane ligand enables highly enantioselective Pd(0)-catalyzed cyclopropane C-H functionalization us ...

American Chemical Society2017

2-(Trifluoromethyl)indoles via Pd(0)-Catalyzed C(sp(3))-H Functionalization of Trifluoroacetimidoyl Chlorides

Nicolai Cramer, Julia Pedroni

Perfluoroalkylated indoles are valuable compounds in drug discovery. A Pd(0)-catalyzed C(sp(3))-H functionalization enables access to 2-(trifluoromethyl)indoles from trifluoroacetimidoyl chlorides. These are stable compounds, easily obtained from anilines. ...

American Chemical Society2016

Chiral gamma-Lactams by Enantioselective Palladium(0)-Catalyzed Cyclopropane Functionalizations

Nicolai Cramer, Julia Pedroni

Cyclopropanes fused to pyrrolidines are important structural features found in a number of marketed drugs and development candidates. Typically, their synthesis involves the cyclopropanation of a dihydropyrrole precursor. Reported herein is a complementary ...

Wiley-VCH Verlag GmbH2015

Enantioselective palladium(0)-catalyzed intramolecular cyclopropane functionalization: access to dihydroquinolones, dihydroisoquinolones and the BMS-791325 ring system

Nicolai Cramer, Tanguy Jean Daniel Saget, Pavel Alexandrovich Donets, Julia Pedroni

Taddol-based phosphoramidite ligands enable enantioselective palladium(0)-catalyzed C-H arylation of cyclopropanes. The cyclized products are obtained in high yields and enantioselectivities. The reported method provides efficient access to a broad range o ...

Royal Soc Chemistry2015

TADDOL-based phosphorus(III)-ligands in enantioselective Pd(0)-catalysed C-H functionalisations

Nicolai Cramer, Julia Pedroni

Monodentate TADDOL-derived phosphoramidites and phosphonites are versatile chiral ligands for enantio-selective Pd(0)-catalysed C-H functionalisations. They enable highly selective cyclisations to access a wide range of chiral carbo-and heterocycles. The h ...

Royal Society of Chemistry2015

Access to beta-Lactams by Enantioselective Palladium(0)-Catalyzed C(sp(3))-H Alkylation

Nicolai Cramer, Tanguy Jean Daniel Saget, Julia Pedroni, Michele Boghi

beta-Lactams are very important structural motifs because of their broad biological activities as well as their propensity to engage in ring-opening reactions. Transitionmetal- catalyzed C-H functionalizations have emerged as strategy enabling yet uncommon ...

Wiley-Blackwell2014